Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levocetirizine
Drug ID BADD_D01272
Description Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine].[L7694] Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine.[L7694] Levocetirizine was granted FDA approval in 1995.[L7694]
Indications and Usage Levocetirizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.
Marketing Status Prescription; OTC; Discontinued
ATC Code R06AE09
DrugBank ID DB06282
KEGG ID D07402
MeSH ID C472067
PubChem ID 1549000
TTD Drug ID D0M8PW
NDC Product Code Not Available
Synonyms levocetirizine | levocetrizine | acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)- | (2-(4-((R)-p-chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)acetic acid | levocetirizine hydrochloride | Xusal | levocetirizine dihydrochloride | (2-(4-((R)-(4-chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride | cetirizine (R)-form dihydrochloride | acetic acid, (2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, dihydrochloride | Xyzal | UCB-28556
Chemical Information
Molecular Formula C21H25ClN2O3
CAS Registry Number 130018-77-8
SMILES C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.001169%
Acne23.02.01.0010.000877%Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.000877%
Aggression19.05.01.0010.000585%Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.0010.000585%Not Available
Alanine aminotransferase increased13.03.01.0030.001462%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.001462%Not Available
Anal fissure07.03.01.0020.000585%
Anal fistula07.11.05.0020.000585%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.001169%
Anaphylactic shock24.06.02.004; 10.01.07.0020.001169%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000877%
Angioedema23.04.01.001; 10.01.05.0090.001754%Not Available
Angle closure glaucoma06.03.01.0010.000585%Not Available
Arrhythmia02.03.02.0010.002631%Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.000877%
Aspartate aminotransferase increased13.03.01.0060.001462%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.000877%
Autoimmune hepatitis09.01.07.019; 10.04.09.0010.000585%Not Available
Back pain15.03.04.005--
Bilirubin conjugated increased13.03.01.0070.000585%Not Available
Blindness17.17.01.003; 06.02.02.0010.000585%Not Available
Blood albumin decreased13.09.01.0010.000585%Not Available
Blood bilirubin increased13.03.01.0080.000585%
Blood fibrinogen decreased13.01.02.0030.000585%
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