Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levetiracetam
Drug ID BADD_D01265
Description Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.[A185927]
Indications and Usage Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX14
DrugBank ID DB01202
KEGG ID D00709
MeSH ID D000077287
PubChem ID 5284583
TTD Drug ID D0E1XL
NDC Product Code 76282-247; 65162-538; 28877-5960; 50474-001; 68180-113; 63739-411; 69367-333; 51991-651; 68001-114; 70518-1921; 51927-0107; 42385-957; 0409-1886; 60505-3517; 16714-034; 70518-1796; 63629-8315; 55111-870; 60687-249; 24689-106; 51552-1448; 50474-597; 47335-576; 16714-358; 55154-7887; 50474-596; 55154-5782; 43485-104; 72865-188; 69102-106; 0121-0799; 63629-4675; 51672-4136; 63323-400; 65841-703; 0378-5617; 0904-6051; 68001-117; 66689-028; 68084-859; 13668-017; 43547-346; 14789-110; 0378-5613; 55111-182; 25021-780; 12666-0014; 68382-168; 52343-071; 16714-355; 35208-031; 13668-016; 16571-788; 43547-221; 31722-574; 68180-112; 65862-245; 54838-548; 63629-4137; 42185-7039; 10370-195; 10370-214; 0121-2397; 61919-559; 0409-2011; 16571-787; 68180-114; 43547-223; 66689-029; 43063-499; 76494-530; 66174-0044; 47133-574; 52343-072; 72789-152; 75834-246; 52038-171; 60505-3518; 80705-101; 76282-246; 76494-529; 71930-063; 51927-0088; 68083-153; 71052-043; 69076-500; 38779-2900; 68001-402; 44567-501; 50090-4023; 70860-602; 16714-357; 64980-365; 65862-247; 62331-010; 0904-7060; 68084-882; 51672-4141; 50474-599; 68083-152; 47335-573; 68554-0065; 68001-115; 67457-790; 68084-870; 55154-5699; 0615-7978; 0121-4799; 71093-144; 43485-102; 64980-363; 65162-529; 0378-5615; 65162-528; 16729-065; 70518-2320; 63187-360; 43485-103; 69102-107; 0904-7124; 50228-190; 0904-6052; 72189-190; 50090-3518; 71930-065; 68001-405; 0143-9574; 16571-789; 67296-1248; 70518-0947; 55111-183; 63739-787; 36998-0117; 68180-117; 65862-261; 55154-3367; 71335-0139; 64980-362; 16714-310; 17856-0574; 68084-893; 72865-189; 0904-7123; 60432-831; 43547-222; 60429-349; 50228-189; 68071-4508; 68180-118; 0395-8160; 50268-470; 71930-062; 50090-2456; 36998-5980; 69339-157; 64220-192; 68788-7074; 13668-014; 72485-106; 69367-332; 35208-032; 55111-248; 61919-068; 65372-1148; 16714-035; 36998-5950; 28877-5970; 69076-750; 70518-1969; 51672-4142; 68083-154; 52343-069; 52343-070; 50474-598; 65862-315; 51672-4137; 61919-552; 36998-5960; 51927-0155; 72643-025; 71901-605; 16571-790; 81414-001; 44567-502; 71205-880; 65841-704; 68382-165; 66689-030; 0904-7125; 68001-404; 70166-081; 51927-4721; 63629-7516; 58032-0132; 55154-7647; 13668-015; 43063-617; 50383-241; 69102-108; 67296-1636; 51079-821; 50090-2875; 16714-356; 36998-5970; 65862-246; 0472-0235; 43489-122; 69102-105; 81646-116; 62756-880; 50090-3264; 50228-472; 71335-0748; 71335-0048; 0121-1598; 75834-245; 68001-118; 14789-330; 71930-064; 61919-685; 14789-220; 50090-3889; 81665-100; 50474-594; 68001-113; 16714-354; 16729-067; 57572-0034; 63739-019; 55150-177; 42385-955; 65162-685; 58118-1112; 68788-7430; 42385-956; 76282-248; 70518-2810; 50228-473; 50090-1333; 67835-0006; 71335-0702; 70518-3317; 31722-539; 68180-115; 67457-266; 31722-538; 71335-0694; 64220-152; 66689-102; 43547-224; 47133-575; 36998-5990; 64376-697; 50474-002; 16729-064; 39822-4000; 76494-531; 70860-604; 62512-0030; 43547-345; 42385-954; 72640-004; 0615-7979; 80705-100; 51672-4143; 70860-603; 76494-528; 50090-5495; 44567-500; 50090-5760; 67457-265; 65162-539; 64980-364; 68001-116; 43489-124; 72969-039; 16729-066; 68788-7884; 72865-187; 68180-099; 72189-229; 70518-2230; 0615-7976; 0378-5619; 36998-5940; 31722-536; 43485-101; 68788-7534; 55111-181; 72865-190; 51224-013; 42571-331; 70518-1998; 60429-350; 0904-6053; 67457-255; 63629-2073; 70518-2328; 65862-250; 50474-595; 50683-0322; 60505-3280; 70518-1901; 62350-0059; 0143-9673; 31722-537; 68001-403; 71205-881; 70518-3192; 44567-503; 55289-097; 28877-5950; 63739-795; 68225-021; 0615-7977; 16714-537
Synonyms Levetiracetam | Etiracetam, S-isomer | Etiracetam, S isomer | S-isomer Etiracetam | Ucb L059 | Ucb-L059 | UCB 6474 | UCB-6474 | UCB6474 | Etiracetam, R-isomer | Etiracetam, R isomer | R-isomer Etiracetam | Etiracetam, (R)- | Keppra | Etiracetam | alpha-ethyl-2-oxo-1-Pyrrolidineacetamide | alpha ethyl 2 oxo 1 Pyrrolidineacetamide | Ucb L060 | Ucb-L060 | UcbL060
Chemical Information
Molecular Formula C8H14N2O2
CAS Registry Number 102767-28-2
SMILES CCC(C(=O)N)N1CCCC1=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Amnesia19.20.01.001; 17.03.02.001--
Amylase increased13.05.01.0090.000381%
Anaemia01.03.02.001--
Anaemia megaloblastic14.12.01.003; 01.03.02.0030.000381%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000994%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anencephaly03.10.03.001; 17.19.03.0010.000646%Not Available
Anger19.04.02.0010.007046%Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anhedonia19.15.02.007--Not Available
Antisocial behaviour19.05.01.010--Not Available
Antisocial personality disorder19.05.03.002--Not Available
Anxiety19.06.02.002--
Apathy19.04.04.0020.001714%Not Available
Aphasia19.21.01.001; 17.02.03.0010.005522%
Aplasia03.02.01.002; 08.03.04.0030.000952%Not Available
Aplasia pure red cell10.02.01.003; 01.03.03.0010.000381%Not Available
Aplastic anaemia01.03.03.0020.000199%Not Available
Apnoea22.02.01.0010.001523%
Apraxia19.21.01.002; 17.02.03.0020.000952%Not Available
Areflexia17.02.01.0010.000571%Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Asocial behaviour19.05.01.011--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.011--Not Available
Aspiration22.02.07.0070.000298%
Asterixis17.01.06.001; 09.01.03.0040.000381%Not Available
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