Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Levetiracetam
Drug ID BADD_D01265
Description Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918] and little-to-no potential to produce, or be subject to, pharmacokinetic interactions[L8606,L8600,L8615] - these characteristics make it a desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic indexes and a propensity for involvement in drug interactions.[A185927]
Indications and Usage Levetiracetam is indicated as an adjunctive therapy in the treatment of partial onset seizures in epileptic patients who are one month of age and older. Additionally, it is indicated as an adjunct in the treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy who are 12 years of age and older, and in primary generalized tonic-clonic seizures in patients with idiopathic generalized epilepsy who are 6 years of age and older.[L8606] Levetiracetam is also available as an orally dissolvable tablet that is indicated as an adjunct in the treatment of partial onset seizures in patients with epilepsy who are 4 years of age and older and weigh more than 20kg.[L8609]
Marketing Status approved
ATC Code N03AX14
DrugBank ID DB01202
KEGG ID D00709
MeSH ID D000077287
PubChem ID 5284583
TTD Drug ID D0E1XL
NDC Product Code 76494-528; 36998-5960; 0904-7265; 58032-0132; 66174-0044; 16729-064; 25021-780; 27808-263; 31722-537; 42385-956; 42385-957; 43063-499; 43063-617; 43485-102; 44567-501; 47335-573; 47335-576; 50090-1333; 50090-2456; 50405-302; 51224-013; 51672-4137; 51672-4143; 55150-177; 60687-668; 61919-559; 62135-548; 63739-019; 63739-787; 66689-030; 67296-1486; 67877-770; 67877-771; 68180-112; 68180-118; 69102-105; 70518-3317; 71930-064; 72205-037; 76282-248; 80705-101; 55111-870; 65862-245; 72643-025; 82623-501; 13668-015; 13668-017; 14789-110; 16571-789; 16571-790; 27808-264; 0121-4799; 43485-103; 43547-223; 43547-345; 44567-503; 51672-4142; 60687-657; 63187-360; 63739-158; 63739-411; 64980-362; 67296-1248; 68001-405; 0409-2011; 68382-168; 69102-106; 70518-1772; 70518-3742; 70518-3765; 71205-880; 0615-7979; 72205-095; 12666-0014; 28877-5950; 36998-0117; 51927-0088; 57572-0034; 64220-192; 65372-1148; 72640-004; 16714-537; 16729-067; 27808-266; 42385-954; 0143-9574; 43485-104; 50474-597; 51672-4136; 61919-552; 63629-4137; 63629-8315; 64980-364; 64980-365; 65862-247; 65862-250; 66689-029; 68001-113; 68083-152; 68084-882; 68084-893; 69367-332; 70860-602; 71093-144; 71335-0748; 71335-2098; 0615-7978; 71930-063; 72189-190; 64980-363; 65162-685; 65841-703; 65841-704; 66689-028; 67457-265; 67457-266; 68083-154; 68180-114; 68382-165; 68788-7430; 70518-1998; 72189-229; 76494-529; 82009-123; 0904-7124; 62512-0030; 65862-246; 65862-261; 65862-315; 75834-246; 13668-014; 16714-310; 16714-357; 16729-065; 24689-106; 0143-9673; 47133-574; 50228-473; 60429-349; 63629-4675; 0378-5615; 65162-538; 66689-102; 67877-769; 68084-859; 68180-113; 0409-1886; 0472-0235; 70518-1827; 71205-728; 71205-881; 71335-0139; 71335-0702; 72205-096; 72485-106; 76494-531; 82009-122; 36998-5950; 38779-2900; 51927-0155; 64220-152; 71901-605; 81414-001; 16729-066; 31722-539; 42385-955; 43547-454; 50228-470; 50405-303; 55111-181; 63739-795; 67877-768; 68001-403; 68071-4508; 68083-153; 68084-870; 68180-099; 68788-7884; 70518-1921; 71930-065; 72205-120; 72865-188; 76282-246; 76494-530; 36998-5980; 36998-5990; 42185-7039; 51552-1448; 52038-171; 69037-0074; 71052-043; 16714-034; 16714-035; 16714-355; 16714-356; 35208-031; 35208-032; 0121-1598; 42571-331; 43547-221; 43547-222; 50090-6378; 50228-190; 50228-471; 50268-470; 50474-002; 50474-598; 50474-599; 55111-182; 55111-183; 55154-4171; 55154-5782; 60505-3517; 60505-3518; 63323-400; 0378-5619; 65162-528; 65162-529; 68001-404; 68788-8254; 69102-107; 70518-1108; 70518-2109; 70518-3534; 70860-604; 71335-0694; 72572-360; 72865-189; 82009-124; 28877-5960; 68225-021; 13668-016; 14789-330; 16571-787; 16714-358; 0121-0799; 43547-224; 43547-346; 44567-502; 50090-3889; 50228-189; 60429-350; 60505-3280; 60687-249; 63629-9615; 65162-539; 68180-117; 70518-3769; 70860-603; 71930-062; 72205-097; 72789-152; 80705-100; 82009-121; 0904-7125; 62991-3189; 16571-788; 31722-574; 44567-500; 47133-575; 50090-2875; 50090-6086; 50383-241; 50405-301; 51079-821; 51672-4141; 55154-5699; 63629-7516; 0378-5617; 67457-255; 68001-114; 68001-402; 68180-115; 69102-108; 69339-157; 69367-333; 70518-0947; 70518-1796; 70518-1901; 70518-2230; 75834-245; 76282-247; 28877-0117; 28877-5970; 50683-0322; 62350-0059; 68554-0065; 14789-220; 16714-354; 31722-536; 39822-4000; 50228-472; 50405-300; 51655-325; 58118-1112; 61919-685; 67457-790; 70518-3770; 71335-0048; 0615-7976; 0615-7977; 72205-094; 72865-187; 72865-190; 0904-7123; 36998-5940; 36998-5970; 62331-010; 67835-0006; 27808-265; 31722-538; 0121-2397; 43485-101; 50474-001; 50474-594; 50474-595; 50474-596; 51991-651; 55111-248; 55154-3367
UNII 44YRR34555
Synonyms Levetiracetam | Etiracetam, S-isomer | Etiracetam, S isomer | S-isomer Etiracetam | Ucb L059 | Ucb-L059 | UCB 6474 | UCB-6474 | UCB6474 | Etiracetam, R-isomer | Etiracetam, R isomer | R-isomer Etiracetam | Etiracetam, (R)- | Keppra | Etiracetam | alpha-ethyl-2-oxo-1-Pyrrolidineacetamide | alpha ethyl 2 oxo 1 Pyrrolidineacetamide | Ucb L060 | Ucb-L060 | UcbL060
Chemical Information
Molecular Formula C8H14N2O2
CAS Registry Number 102767-28-2
SMILES CCC(C(=O)N)N1CCCC1=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin lesion23.03.03.0100.000477%Not Available
Sleep terror19.02.03.008; 17.15.02.0060.000580%Not Available
Sluggishness08.01.01.0040.000238%Not Available
Small cell lung cancer22.08.01.013; 16.19.08.0030.000079%Not Available
Snoring22.12.03.0250.000175%Not Available
Somnolence19.02.05.003; 17.02.04.0060.013197%
Speech disorder22.12.03.027; 19.19.02.002; 17.02.08.0030.000930%Not Available
Splenomegaly01.09.02.0010.000278%Not Available
Staring19.01.01.0030.000413%Not Available
Status epilepticus17.12.03.0050.007385%Not Available
Stereotypy19.11.03.006; 17.01.02.0160.000294%Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.0050.001351%
Stillbirth18.01.02.002; 08.04.01.0060.004770%Not Available
Stomatitis07.05.06.005--
Stupor19.02.05.004; 17.02.04.0070.000676%Not Available
Subarachnoid haemorrhage24.07.04.004; 17.08.01.010; 12.01.10.0110.000318%Not Available
Sudden death08.04.01.003; 02.03.04.0130.000517%
Suicidal ideation19.12.01.0030.005008%
Suicide attempt19.12.01.0040.002862%
Swelling08.01.03.015--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.008--
Systemic lupus erythematosus15.06.02.003; 10.04.03.004; 23.03.02.0060.000914%Not Available
Tearfulness19.15.02.0050.000119%Not Available
Telangiectasia24.03.03.003; 23.06.03.0010.000413%
Tension19.06.02.0050.000238%Not Available
Tension headache19.24.01.009; 17.14.01.0040.000079%Not Available
Teratogenicity12.03.01.032; 03.02.01.004--Not Available
Therapeutic response unexpected08.06.01.0010.001479%Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.001391%Not Available
Thought blocking19.10.03.0030.000119%Not Available
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