Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lenalidomide
Drug ID BADD_D01253
Description Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties.[A228553] It is a 4-amino-glutamyl analogue of [thalidomide] [A228543] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms.[A228708] However, lenalidomide is much safer and potent than thalidomide, with fewer adverse effects and toxicities.[A714, A228543] Thalidomide and its analogues, including lenalidomide, are referred to as immunomodulatory imide drugs (also known as cereblon modulators), which are a class of immunomodulatory drugs that contain an imide group. Lenalidomide works through various mechanisms of actions that promote malignant cell death and enhance host immunity.[A228708] Available as oral capsules, lenalidomide is approved by the FDA and EU for the treatment of multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma in selected patients.[L16028] Lenalidomide is available only under a special restricted distribution program.[A228708]
Indications and Usage Lenalidomide is indicated for the treatment of multiple myeloma in combination with dexamethasone. It is also indicated for the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.
Marketing Status Prescription
ATC Code L04AX04
DrugBank ID DB00480
KEGG ID D04687
MeSH ID D000077269
PubChem ID 216326
NDC Product Code 59572-415; 59572-402; 55488-0700; 0480-1242; 0480-1244; 14096-131; 65727-084; 0480-1246; 59572-420; 59116-4710; 59572-425; 53104-7720; 59572-410; 55111-911; 68554-0090; 71796-026; 0480-1243; 46708-927; 59572-405; 53104-7726; 54893-0061; 82245-0101; 65015-772
Synonyms Lenalidomide | 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione | 2,6-Piperidinedione, 3-(4-amino-1,3-dihydro-1-oxo-2H- isoindol-2-yl)- | IMiD3 Cpd | CC 5013 | CC5013 | CC-5013 | Revlimid | Revimid
Chemical Information
Molecular Formula C13H13N3O3
CAS Registry Number 191732-72-6
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blindness unilateral17.17.01.016; Available
Blister23.03.01.001; Available
Blood albumin decreased13.09.01.001--Not Available
Blood bilirubin increased13.03.01.008--
Blood calcium abnormal13.11.01.0220.008106%Not Available
Blood calcium decreased13.11.01.0020.054425%Not Available
Blood calcium increased13.11.01.0030.031845%Not Available
Blood cholesterol abnormal13.12.01.0090.001737%Not Available
Blood cholesterol increased13.12.01.002--
Blood creatine increased13.13.01.0010.006948%Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine abnormal13.13.01.0020.012738%Not Available
Blood creatinine decreased13.13.01.0030.007527%Not Available
Blood creatinine increased13.13.01.004--
Blood culture positive13.08.02.002--Not Available
Blood glucose abnormal13.02.02.008--Not Available
Blood glucose decreased13.02.02.0010.027792%Not Available
Blood glucose increased13.02.02.002--Not Available
Blood immunoglobulin G decreased13.06.05.0010.002895%Not Available
Blood immunoglobulin G increased13.06.05.0040.010422%Not Available
Blood immunoglobulin M decreased13.06.05.0060.001158%Not Available
Blood iron abnormal13.11.01.0440.003474%Not Available
Blood iron decreased13.11.01.0060.028371%Not Available
Blood iron increased13.11.01.0070.005211%Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood lactic acid increased13.02.01.015--Not Available
Blood magnesium decreased13.11.01.0080.042845%Not Available
Blood parathyroid hormone increased13.10.07.002--Not Available
Blood potassium abnormal13.11.01.0240.011580%Not Available
Blood potassium decreased13.11.01.0100.193962%Not Available
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