Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Latanoprost
Drug ID BADD_D01251
Description Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment.[A184493] It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day.[A184490]
Indications and Usage Latanoprost is indicated for the reduction of elevated intraocular pressure in patients who have been diagnosed with open-angle glaucoma or ocular hypertension.[L8357] Latanoprost may be combined in a product with [Netarsudil], a rho kinase inhibitor, for the same indications.[L8369] In addition to the above indications, the Canadian monograph for this drug also approves latanoprost for the treatment of elevated intraocular pressure as a result of angle-closure glaucoma that has been treated with peripheral iridotomy or laser iridoplasty.[L8366]
Marketing Status approved; investigational
ATC Code S01EE01
DrugBank ID DB00654
KEGG ID D00356
MeSH ID D000077338
PubChem ID 5311221
TTD Drug ID D0C6NM
NDC Product Code 65727-026; 82187-1002; 71205-154; 62991-3186; 65427-007; 82231-111; 50090-1920; 59762-0333; 54893-0010; 63190-0710; 65326-004; 61314-547; 65862-872; 0009-5172; 12079-0475; 42385-039; 51552-1385; 51927-4864; 68245-0002; 81997-001; 10695-048; 90027-006; 47335-317; 70069-421; 65035-128; 71684-0547; 73212-027; 55545-0462; 71052-041; 24208-463; 64980-516; 68071-4612; 40016-001; 61556-050; 0013-8303; 24002-0018; 73377-237
UNII 6Z5B6HVF6O
Synonyms Latanoprost | PhXA34 | PHXA41 | Xalatan
Chemical Information
Molecular Formula C26H40O5
CAS Registry Number 130209-82-4
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.009--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Choroidal detachment12.01.04.006; 06.09.01.0030.000112%Not Available
Condition aggravated08.01.03.004--Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.0010.000225%Not Available
Conjunctivitis06.04.01.002; 11.01.06.012--
Conjunctivitis allergic10.01.04.002; 06.04.01.0030.000198%Not Available
Corneal degeneration06.06.03.0010.000067%Not Available
Corneal epithelium defect06.06.03.0120.000157%Not Available
Corneal erosion06.06.03.003--Not Available
Corneal lesion06.06.03.004--Not Available
Corneal oedema06.04.02.0010.000112%Not Available
Corneal opacity06.06.03.0050.000112%Not Available
Corneal scar12.01.04.015; 06.06.03.0150.000090%Not Available
Cough22.02.03.0010.000891%
Dementia19.20.02.001; 17.03.01.0010.000067%Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis allergic23.03.04.003; 10.01.03.014--Not Available
Dermatitis atopic10.01.04.004; 23.03.04.016--Not Available
Diabetic retinopathy24.03.07.004; 14.07.01.002; 06.10.02.002; 05.07.01.0020.000045%Not Available
Diplopia17.17.01.005; 06.02.06.0020.000243%Not Available
Discomfort08.01.08.0030.000166%Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Drug hypersensitivity10.01.01.0010.003054%Not Available
Drug ineffective08.06.01.0060.007431%Not Available
Dry eye06.08.02.0010.002195%
Dry throat22.12.03.005; 07.06.01.0050.000198%Not Available
Dysphonia22.12.03.006; 19.19.03.002; 17.02.08.0040.000243%
Dyspnoea02.11.05.003; 22.02.01.004--
Ectropion23.07.05.001; 06.06.04.0010.000045%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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