Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lansoprazole
Drug ID BADD_D01245
Description Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies caused by excessive acid secretion.[A177053]
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BC03
DrugBank ID DB00448
KEGG ID D00355
MeSH ID D064747
PubChem ID 3883
TTD Drug ID D06YYD
NDC Product Code 60687-111; 0113-7116; 68788-6390; 71335-0575; 38779-2289; 71335-0043; 0363-4069; 65015-658; 46122-698; 65628-080; 64764-046; 0093-7350; 11532-1441; 49035-373; 53104-7526; 62175-415; 72288-343; 52932-0730; 11673-117; 70700-263; 66332-1443; 0093-3009; 64679-140; 0904-6662; 55111-044; 64679-669; 49452-3041; 43598-560; 41520-816; 67877-275; 63629-2342; 59779-117; 67877-274; 11532-1440; 63629-4851; 68071-3019; 55111-399; 69256-401; 50090-4596; 50090-5180; 42291-433; 31722-571; 49348-301; 30142-288; 49711-0110; 0378-8015; 72288-829; 0113-0116; 68071-4456; 68382-772; 41250-391; 72288-301; 51838-123; 70700-262; 42765-023; 72476-020; 70771-1132; 68788-7742; 0378-8030; 0536-1324; 41250-117; 70677-0124; 31722-570; 59349-0015; 0536-1236; 63629-7552; 64764-541; 68071-5119; 63739-555; 71335-0917; 71052-242; 62175-430; 62756-252; 61919-890; 51927-3877; 68382-771; 68071-2274; 68001-111; 60687-123; 65841-770; 41163-117; 63981-582; 11822-0117; 62011-0472; 63187-510; 11822-3374; 69842-270; 62175-515; 70000-0508; 0781-2148; 0113-6002; 55154-0253; 63629-2340; 50090-2225; 55289-704; 56062-283; 27241-020; 36800-392; 0113-0117; 30142-117; 70771-1133; 72189-279; 71335-1820; 49035-739; 71335-1425; 79903-068; 27241-019; 0363-0739; 52562-021; 43598-561; 55111-739; 68788-7789; 30142-192; 63415-0060; 65372-1136; 63187-152; 45865-879; 45802-878; 65977-0013; 11673-280; 56062-117; 69842-755; 0781-2147; 50090-3195; 37012-117; 43598-883; 0067-6286; 16714-186; 62011-0168; 66332-1442; 42291-365; 51079-121; 68391-117; 80425-0174; 63850-3309; 63629-2341; 55910-117; 68001-112; 16571-698; 0378-6981; 63868-429; 0378-6982; 71335-1521; 46122-107; 16714-185; 64764-543; 16571-697; 36800-295; 51552-1239; 64764-544; 51927-0064; 0093-3008; 21130-181; 55154-4848; 57896-761; 63981-117; 42291-364; 55910-307; 45802-245; 69842-507; 64679-670; 16571-742; 68382-543; 0363-1419; 81522-001; 70000-0069; 68016-758; 80425-0148; 68382-544; 70756-806; 70756-807; 0113-1114; 0093-7351; 71335-0058; 42291-434; 41163-150; 68788-7385; 0378-3995; 51407-324; 65841-769; 49035-411; 72189-062; 37808-755; 64374-007; 0113-7003; 55111-398; 61919-245; 61919-655; 0363-1212; 60760-544; 36800-117; 71335-0105
Synonyms Lansoprazole | Lansoprazol | 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole | Lansoprazoles | Ogastro | AG 1749 | AG-1749 | AG1749 | Agopton | Bamalite | Lansol | Lansoprazole Sodium | Sodium, Lansoprazole | Lanzor | Monolitum | Opiren | Prevacid | Pro Ulco | Promeco | Takepron | Ulpax | Zoton | Ogast | Prezal
Chemical Information
Molecular Formula C16H14F3N3O2S
CAS Registry Number 103577-45-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.0010.001676%Not Available
Hepatic steatosis14.08.04.005; 09.01.07.0030.000419%Not Available
Hepatitis09.01.07.0040.002514%Not Available
Hepatocellular injury09.01.07.0080.003352%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hernia08.01.04.0010.000419%Not Available
Hiatus hernia22.09.02.004; 07.16.01.0010.000419%Not Available
Hiccups07.01.06.009; 22.02.04.002--
Hostility19.05.01.003--Not Available
Hunger14.03.02.012; 08.01.09.003--Not Available
Hyperaemia24.03.02.0020.001048%Not Available
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.0030.001048%Not Available
Hyperchlorhydria07.11.03.0010.001886%Not Available
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.0280.002933%
Hyperkalaemia14.05.03.0010.001048%
Hyperkinesia17.01.02.008--Not Available
Hyperprolactinaemia05.03.01.0020.000629%Not Available
Hypersensitivity10.01.03.0030.013409%
Hypertension24.08.02.001--
Hypertensive crisis24.08.01.0010.000629%Not Available
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypoaesthesia17.02.06.0230.002933%Not Available
Hypocalcaemia14.04.01.0040.010266%
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypoglycaemic coma14.06.03.004; 05.06.03.004; 17.02.09.0050.000419%Not Available
Hypokalaemia14.05.03.0020.009219%
Hypokinesia17.01.02.0090.000629%Not Available
Hypomagnesaemia14.04.02.0010.011314%
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