Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lansoprazole
Drug ID BADD_D01245
Description Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies caused by excessive acid secretion.[A177053]
Indications and Usage For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.
Marketing Status Prescription; OTC; Discontinued
ATC Code A02BC03
DrugBank ID DB00448
KEGG ID D00355
MeSH ID D064747
PubChem ID 3883
TTD Drug ID D06YYD
NDC Product Code 60687-111; 0113-7116; 68788-6390; 71335-0575; 38779-2289; 71335-0043; 0363-4069; 65015-658; 46122-698; 65628-080; 64764-046; 0093-7350; 11532-1441; 49035-373; 53104-7526; 62175-415; 72288-343; 52932-0730; 11673-117; 70700-263; 66332-1443; 0093-3009; 64679-140; 0904-6662; 55111-044; 64679-669; 49452-3041; 43598-560; 41520-816; 67877-275; 63629-2342; 59779-117; 67877-274; 11532-1440; 63629-4851; 68071-3019; 55111-399; 69256-401; 50090-4596; 50090-5180; 42291-433; 31722-571; 49348-301; 30142-288; 49711-0110; 0378-8015; 72288-829; 0113-0116; 68071-4456; 68382-772; 41250-391; 72288-301; 51838-123; 70700-262; 42765-023; 72476-020; 70771-1132; 68788-7742; 0378-8030; 0536-1324; 41250-117; 70677-0124; 31722-570; 59349-0015; 0536-1236; 63629-7552; 64764-541; 68071-5119; 63739-555; 71335-0917; 71052-242; 62175-430; 62756-252; 61919-890; 51927-3877; 68382-771; 68071-2274; 68001-111; 60687-123; 65841-770; 41163-117; 63981-582; 11822-0117; 62011-0472; 63187-510; 11822-3374; 69842-270; 62175-515; 70000-0508; 0781-2148; 0113-6002; 55154-0253; 63629-2340; 50090-2225; 55289-704; 56062-283; 27241-020; 36800-392; 0113-0117; 30142-117; 70771-1133; 72189-279; 71335-1820; 49035-739; 71335-1425; 79903-068; 27241-019; 0363-0739; 52562-021; 43598-561; 55111-739; 68788-7789; 30142-192; 63415-0060; 65372-1136; 63187-152; 45865-879; 45802-878; 65977-0013; 11673-280; 56062-117; 69842-755; 0781-2147; 50090-3195; 37012-117; 43598-883; 0067-6286; 16714-186; 62011-0168; 66332-1442; 42291-365; 51079-121; 68391-117; 80425-0174; 63850-3309; 63629-2341; 55910-117; 68001-112; 16571-698; 0378-6981; 63868-429; 0378-6982; 71335-1521; 46122-107; 16714-185; 64764-543; 16571-697; 36800-295; 51552-1239; 64764-544; 51927-0064; 0093-3008; 21130-181; 55154-4848; 57896-761; 63981-117; 42291-364; 55910-307; 45802-245; 69842-507; 64679-670; 16571-742; 68382-543; 0363-1419; 81522-001; 70000-0069; 68016-758; 80425-0148; 68382-544; 70756-806; 70756-807; 0113-1114; 0093-7351; 71335-0058; 42291-434; 41163-150; 68788-7385; 0378-3995; 51407-324; 65841-769; 49035-411; 72189-062; 37808-755; 64374-007; 0113-7003; 55111-398; 61919-245; 61919-655; 0363-1212; 60760-544; 36800-117; 71335-0105
Synonyms Lansoprazole | Lansoprazol | 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole | Lansoprazoles | Ogastro | AG 1749 | AG-1749 | AG1749 | Agopton | Bamalite | Lansol | Lansoprazole Sodium | Sodium, Lansoprazole | Lanzor | Monolitum | Opiren | Prevacid | Pro Ulco | Promeco | Takepron | Ulpax | Zoton | Ogast | Prezal
Chemical Information
Molecular Formula C16H14F3N3O2S
CAS Registry Number 103577-45-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aphthous ulcer07.05.06.0020.000419%Not Available
Aplastic anaemia01.03.03.002--Not Available
Apnoea22.02.01.0010.000629%
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.0010.000629%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.000838%
Arthropathy15.01.01.003--Not Available
Ascites09.01.05.003; 07.07.01.001; 02.05.04.002--
Aspartate aminotransferase increased13.03.01.0060.001048%
Aspiration22.02.07.0070.000164%
Asthenia08.01.01.0010.007961%Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrial fibrillation02.03.03.002--
Atrioventricular block complete02.03.01.0030.000629%
Atrioventricular block second degree02.03.01.0050.000419%
Autoimmune hepatitis10.04.09.001; 09.01.07.0190.000629%Not Available
Back pain15.03.04.005--
Bacteraemia11.01.11.0010.000419%
Barrett's oesophagus07.11.03.0020.000419%Not Available
Bezoar07.11.01.008--Not Available
Bile duct cancer16.07.01.001; 09.04.02.0010.000109%Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blister23.03.01.001; 12.01.06.0020.001048%Not Available
Blood albumin decreased13.09.01.0010.000164%Not Available
Blood bilirubin increased13.03.01.0080.001048%
Blood calcium decreased13.11.01.0020.001257%Not Available
Blood cholesterol decreased13.12.01.001--Not Available
Blood cholesterol increased13.12.01.002--
Blood creatine phosphokinase increased13.04.01.0010.001676%
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