Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamotrigine
Drug ID BADD_D01243
Description Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]
Indications and Usage Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (≥18 years of age) treated for acute mood episodes with standard therapy [FDA Label].
Marketing Status Prescription; Discontinued
ATC Code N03AX09
DrugBank ID DB00555
KEGG ID D00354
MeSH ID D000077213
PubChem ID 3878
TTD Drug ID D03FLC
NDC Product Code 29300-114; 13668-342; 0173-0779; 69102-312; 58437-021; 50228-319; 62332-038; 67835-0016; 68462-228; 55111-222; 61919-802; 65841-686; 69102-359; 51672-4139; 58437-023; 67877-166; 55700-683; 0173-0526; 59746-247; 65162-986; 50228-320; 0173-0699; 51407-062; 68382-006; 71335-1469; 0904-7008; 0115-1529; 65841-682; 68788-7544; 46708-276; 69102-137; 16714-893; 55111-720; 16714-700; 64679-275; 55111-043; 16714-701; 55289-410; 42291-443; 70518-1523; 53002-1512; 65862-362; 65015-626; 65841-687; 70518-2406; 65862-227; 69102-319; 43063-259; 59917-077; 42291-447; 68788-6868; 69097-148; 67877-165; 0173-0643; 70518-3109; 68382-010; 63187-744; 61919-534; 49884-487; 49884-486; 55111-428; 66406-0281; 60760-549; 68382-979; 0615-8267; 69097-152; 51927-0021; 29300-112; 43063-238; 71335-1919; 43598-551; 59917-078; 27241-183; 72888-028; 51407-063; 16714-196; 53002-2512; 70518-2535; 11014-0155; 27241-184; 76420-182; 0173-0776; 12658-0579; 72888-027; 70518-3150; 46708-274; 68382-108; 0615-7964; 69097-151; 65862-229; 55154-2330; 51672-4132; 59746-246; 46708-853; 65372-1103; 68382-011; 27241-186; 65862-228; 69918-360; 0173-0817; 58118-2148; 0173-0644; 72789-206; 12658-0578; 16714-623; 71335-1748; 70518-2563; 58437-022; 65841-689; 0173-0754; 71335-0830; 55111-718; 64679-274; 62332-037; 70518-2577; 51552-1361; 16571-785; 51672-4133; 55111-419; 55111-719; 69102-301; 70518-2645; 71335-0706; 50228-322; 63629-8283; 70518-2697; 43063-202; 0115-9940; 55111-221; 59917-079; 69918-370; 42291-369; 0115-1527; 50090-5567; 0173-0758; 51672-4140; 53747-016; 70518-2716; 70518-1908; 55111-226; 55154-2065; 58437-019; 60760-474; 68788-7871; 13668-045; 0173-0774; 0228-1453; 13668-049; 17511-103; 68382-009; 65841-683; 14799-2011; 68382-981; 0615-8150; 68382-980; 53296-0059; 16714-703; 16714-624; 0173-0633; 0395-8217; 0173-0760; 55111-717; 69097-149; 65862-361; 68382-982; 12666-0005; 67877-164; 16714-627; 69918-380; 72888-025; 65841-684; 0904-7007; 42291-446; 65862-266; 70518-3139; 66406-0284; 50090-2130; 58437-020; 49884-881; 63187-487; 72189-063; 13668-341; 68788-7223; 0228-1435; 13668-266; 71335-1110; 0115-9941; 16714-702; 0115-9942; 70518-1479; 50090-4939; 55111-223; 51672-4130; 70518-2889; 62332-040; 68788-7168; 69918-350; 0173-0642; 63629-4697; 0173-0781; 71335-0044; 69102-150; 50090-3914; 55154-2331; 62332-096; 62332-039; 16714-195; 51407-060; 53104-7606; 59746-248; 65162-990; 71205-245; 11014-0157; 0173-0755; 16714-194; 69102-300; 49884-882; 70518-3187; 0173-0778; 0228-1410; 66406-0282; 65162-988; 65841-685; 0115-9939; 50090-5828; 13668-340; 62331-047; 72888-026; 68382-983; 51407-061; 13668-048; 27241-185; 55111-220; 65862-230; 64679-273; 62332-095; 68382-109; 0228-1580; 60760-050; 49884-484; 42291-368; 49711-0111; 16714-626; 0173-0759; 43598-550; 69102-306; 49884-880; 53002-1513; 64679-272; 43598-553; 68022-7036; 59285-023; 68382-984; 0173-0777; 50090-2129; 64679-271; 58437-024; 68462-229; 0228-1638; 67877-167; 43598-552; 16714-625; 0173-0757; 59917-080; 58118-1111; 71335-1179; 65162-949; 0173-0756; 66406-0283; 71335-1579; 49884-485; 70518-3043; 0115-1526; 16714-197; 68382-008; 13668-339; 65162-956; 0228-1422; 69102-639; 50228-321; 53002-2513; 59746-245; 13668-047; 68084-319; 46708-275; 42291-366; 42419-012; 0173-0527; 0173-0761; 65162-958; 50090-5827; 46708-277; 0173-0780; 70518-2503; 55700-626; 29300-111; 16571-786; 65841-690; 68382-007; 42291-444; 51672-4131; 68084-318; 0115-1528; 70518-1978; 42291-448; 69102-320; 50090-2131; 0615-7975; 0173-0772; 43063-203; 50090-5850; 55111-225; 29300-113; 68788-7647; 11014-0154; 42291-445; 70518-2755; 42291-367; 0173-0594; 11014-0156
Synonyms Lamotrigine | 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine | 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine | Lamictal | Crisomet | Lamiktal | BW-430C | BW 430C | BW430C | Labileno
Chemical Information
Molecular Formula C9H7Cl2N5
CAS Registry Number 84057-84-1
SMILES C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cleft palate07.05.08.001; 03.04.02.0010.002320%Not Available
Clonus17.02.05.0020.000902%Not Available
Clumsiness17.01.02.0050.000902%Not Available
Coarctation of the aorta24.04.01.002; 03.07.08.0010.000370%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.0050.000516%Not Available
Coma17.02.09.0010.005929%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.002219%Not Available
Complex partial seizures17.12.02.0030.000387%Not Available
Conduction disorder02.03.01.0080.000387%
Confusional state19.13.01.001; 17.02.03.0050.010569%
Congenital central nervous system anomaly17.19.01.003; 03.10.02.0040.001418%Not Available
Congenital cystic kidney disease20.01.04.006; 16.27.01.002; 03.06.01.0030.000644%Not Available
Congenital diaphragmatic hernia22.09.02.003; 07.16.01.003; 03.16.03.0010.000437%Not Available
Conjunctival oedema06.04.01.0010.000902%Not Available
Conjunctival ulcer06.04.01.0150.000516%Not Available
Conjunctivitis11.01.06.012; 06.04.01.0020.004511%
Conjunctivitis allergic10.01.04.002; 06.04.01.0030.000258%Not Available
Constipation07.02.02.001--
Convulsion neonatal18.04.04.003; 17.12.03.0170.000644%Not Available
Coordination abnormal17.02.02.0040.002707%Not Available
Corneal abrasion12.01.04.001; 06.11.03.0010.000258%Not Available
Corneal opacity06.06.03.0050.000902%Not Available
Cough22.02.03.001--
Creatinine renal clearance decreased13.13.01.0130.000387%Not Available
Crohn's disease10.02.01.005; 07.08.01.015--Not Available
Crying12.02.11.001; 08.01.03.005; 19.04.02.002; 17.02.05.0130.007475%Not Available
Cushing's syndrome19.07.03.002; 14.11.01.007; 05.01.01.001; 24.08.04.001--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.001160%
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