Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamotrigine
Drug ID BADD_D01243
Description Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]
Indications and Usage Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (≥18 years of age) treated for acute mood episodes with standard therapy [FDA Label].
Marketing Status Prescription; Discontinued
ATC Code N03AX09
DrugBank ID DB00555
KEGG ID D00354
MeSH ID D000077213
PubChem ID 3878
TTD Drug ID D03FLC
NDC Product Code 29300-114; 13668-342; 0173-0779; 69102-312; 58437-021; 50228-319; 62332-038; 67835-0016; 68462-228; 55111-222; 61919-802; 65841-686; 69102-359; 51672-4139; 58437-023; 67877-166; 55700-683; 0173-0526; 59746-247; 65162-986; 50228-320; 0173-0699; 51407-062; 68382-006; 71335-1469; 0904-7008; 0115-1529; 65841-682; 68788-7544; 46708-276; 69102-137; 16714-893; 55111-720; 16714-700; 64679-275; 55111-043; 16714-701; 55289-410; 42291-443; 70518-1523; 53002-1512; 65862-362; 65015-626; 65841-687; 70518-2406; 65862-227; 69102-319; 43063-259; 59917-077; 42291-447; 68788-6868; 69097-148; 67877-165; 0173-0643; 70518-3109; 68382-010; 63187-744; 61919-534; 49884-487; 49884-486; 55111-428; 66406-0281; 60760-549; 68382-979; 0615-8267; 69097-152; 51927-0021; 29300-112; 43063-238; 71335-1919; 43598-551; 59917-078; 27241-183; 72888-028; 51407-063; 16714-196; 53002-2512; 70518-2535; 11014-0155; 27241-184; 76420-182; 0173-0776; 12658-0579; 72888-027; 70518-3150; 46708-274; 68382-108; 0615-7964; 69097-151; 65862-229; 55154-2330; 51672-4132; 59746-246; 46708-853; 65372-1103; 68382-011; 27241-186; 65862-228; 69918-360; 0173-0817; 58118-2148; 0173-0644; 72789-206; 12658-0578; 16714-623; 71335-1748; 70518-2563; 58437-022; 65841-689; 0173-0754; 71335-0830; 55111-718; 64679-274; 62332-037; 70518-2577; 51552-1361; 16571-785; 51672-4133; 55111-419; 55111-719; 69102-301; 70518-2645; 71335-0706; 50228-322; 63629-8283; 70518-2697; 43063-202; 0115-9940; 55111-221; 59917-079; 69918-370; 42291-369; 0115-1527; 50090-5567; 0173-0758; 51672-4140; 53747-016; 70518-2716; 70518-1908; 55111-226; 55154-2065; 58437-019; 60760-474; 68788-7871; 13668-045; 0173-0774; 0228-1453; 13668-049; 17511-103; 68382-009; 65841-683; 14799-2011; 68382-981; 0615-8150; 68382-980; 53296-0059; 16714-703; 16714-624; 0173-0633; 0395-8217; 0173-0760; 55111-717; 69097-149; 65862-361; 68382-982; 12666-0005; 67877-164; 16714-627; 69918-380; 72888-025; 65841-684; 0904-7007; 42291-446; 65862-266; 70518-3139; 66406-0284; 50090-2130; 58437-020; 49884-881; 63187-487; 72189-063; 13668-341; 68788-7223; 0228-1435; 13668-266; 71335-1110; 0115-9941; 16714-702; 0115-9942; 70518-1479; 50090-4939; 55111-223; 51672-4130; 70518-2889; 62332-040; 68788-7168; 69918-350; 0173-0642; 63629-4697; 0173-0781; 71335-0044; 69102-150; 50090-3914; 55154-2331; 62332-096; 62332-039; 16714-195; 51407-060; 53104-7606; 59746-248; 65162-990; 71205-245; 11014-0157; 0173-0755; 16714-194; 69102-300; 49884-882; 70518-3187; 0173-0778; 0228-1410; 66406-0282; 65162-988; 65841-685; 0115-9939; 50090-5828; 13668-340; 62331-047; 72888-026; 68382-983; 51407-061; 13668-048; 27241-185; 55111-220; 65862-230; 64679-273; 62332-095; 68382-109; 0228-1580; 60760-050; 49884-484; 42291-368; 49711-0111; 16714-626; 0173-0759; 43598-550; 69102-306; 49884-880; 53002-1513; 64679-272; 43598-553; 68022-7036; 59285-023; 68382-984; 0173-0777; 50090-2129; 64679-271; 58437-024; 68462-229; 0228-1638; 67877-167; 43598-552; 16714-625; 0173-0757; 59917-080; 58118-1111; 71335-1179; 65162-949; 0173-0756; 66406-0283; 71335-1579; 49884-485; 70518-3043; 0115-1526; 16714-197; 68382-008; 13668-339; 65162-956; 0228-1422; 69102-639; 50228-321; 53002-2513; 59746-245; 13668-047; 68084-319; 46708-275; 42291-366; 42419-012; 0173-0527; 0173-0761; 65162-958; 50090-5827; 46708-277; 0173-0780; 70518-2503; 55700-626; 29300-111; 16571-786; 65841-690; 68382-007; 42291-444; 51672-4131; 68084-318; 0115-1528; 70518-1978; 42291-448; 69102-320; 50090-2131; 0615-7975; 0173-0772; 43063-203; 50090-5850; 55111-225; 29300-113; 68788-7647; 11014-0154; 42291-445; 70518-2755; 42291-367; 0173-0594; 11014-0156
Synonyms Lamotrigine | 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine | 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine | Lamictal | Crisomet | Lamiktal | BW-430C | BW 430C | BW430C | Labileno
Chemical Information
Molecular Formula C9H7Cl2N5
CAS Registry Number 84057-84-1
SMILES C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pyelocaliectasis20.01.06.0110.000387%Not Available
Congenital cyst16.02.02.012; 08.03.05.007; 03.02.01.0100.000258%Not Available
Congenital nose malformation22.10.02.003; 03.16.04.0010.000101%Not Available
Vulvar erosion21.08.01.0170.000387%Not Available
Foaming at mouth08.01.03.070; 17.02.05.056; 07.05.05.0190.000644%Not Available
Human herpesvirus 7 infection11.05.02.0320.000387%Not Available
Antipsychotic drug level increased13.17.01.0300.000258%Not Available
Genital erosion21.10.05.0150.000387%Not Available
Neurodevelopmental disorder19.22.02.003; 17.03.05.0020.000902%Not Available
Conduct disorder19.21.04.0020.000387%Not Available
Tachyphrenia19.10.03.010; 17.03.03.0070.000387%Not Available
Perivascular dermatitis23.03.04.0390.000644%Not Available
Excessive eye blinking17.17.02.010; 06.05.01.0040.000387%Not Available
Dermo-hypodermitis23.09.01.021; 11.01.12.0210.000387%Not Available
Prominent epicanthal folds06.06.04.022; 03.01.07.0030.000101%Not Available
Fine motor delay17.01.02.019; 19.22.01.0030.000516%Not Available
Tethered cord syndrome20.03.03.007; 17.10.01.0230.000258%Not Available
Oral mucosal erythema07.05.05.0230.000644%Not Available
Rotavirus infection11.05.20.0020.000773%Not Available
Apparent death08.01.03.0620.000258%Not Available
Pure white cell aplasia01.03.03.0130.000258%Not Available
Gastroenteritis norovirus11.05.22.001; 07.19.03.0170.000773%Not Available
Congenital inguinal hernia07.16.02.003; 03.04.07.0050.000516%Not Available
Tubulointerstitial nephritis and uveitis syndrome20.05.02.004; 10.02.01.065; 06.04.03.0060.003480%Not Available
Gross motor delay19.22.01.004; 17.01.02.0210.000258%Not Available
Decreased eye contact19.01.02.012; 17.02.05.0550.000258%Not Available
Retinal phototoxicity12.01.04.030; 06.09.03.0230.001804%Not Available
Escherichia test positive13.08.01.0090.000258%Not Available
Executive dysfunction19.21.02.0100.000258%Not Available
Motor developmental delay19.22.01.005; 17.01.02.0230.000773%Not Available
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