Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamotrigine
Drug ID BADD_D01243
Description Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]
Indications and Usage Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (≥18 years of age) treated for acute mood episodes with standard therapy [FDA Label].
Marketing Status Prescription; Discontinued
ATC Code N03AX09
DrugBank ID DB00555
KEGG ID D00354
MeSH ID D000077213
PubChem ID 3878
TTD Drug ID D03FLC
NDC Product Code 29300-114; 13668-342; 0173-0779; 69102-312; 58437-021; 50228-319; 62332-038; 67835-0016; 68462-228; 55111-222; 61919-802; 65841-686; 69102-359; 51672-4139; 58437-023; 67877-166; 55700-683; 0173-0526; 59746-247; 65162-986; 50228-320; 0173-0699; 51407-062; 68382-006; 71335-1469; 0904-7008; 0115-1529; 65841-682; 68788-7544; 46708-276; 69102-137; 16714-893; 55111-720; 16714-700; 64679-275; 55111-043; 16714-701; 55289-410; 42291-443; 70518-1523; 53002-1512; 65862-362; 65015-626; 65841-687; 70518-2406; 65862-227; 69102-319; 43063-259; 59917-077; 42291-447; 68788-6868; 69097-148; 67877-165; 0173-0643; 70518-3109; 68382-010; 63187-744; 61919-534; 49884-487; 49884-486; 55111-428; 66406-0281; 60760-549; 68382-979; 0615-8267; 69097-152; 51927-0021; 29300-112; 43063-238; 71335-1919; 43598-551; 59917-078; 27241-183; 72888-028; 51407-063; 16714-196; 53002-2512; 70518-2535; 11014-0155; 27241-184; 76420-182; 0173-0776; 12658-0579; 72888-027; 70518-3150; 46708-274; 68382-108; 0615-7964; 69097-151; 65862-229; 55154-2330; 51672-4132; 59746-246; 46708-853; 65372-1103; 68382-011; 27241-186; 65862-228; 69918-360; 0173-0817; 58118-2148; 0173-0644; 72789-206; 12658-0578; 16714-623; 71335-1748; 70518-2563; 58437-022; 65841-689; 0173-0754; 71335-0830; 55111-718; 64679-274; 62332-037; 70518-2577; 51552-1361; 16571-785; 51672-4133; 55111-419; 55111-719; 69102-301; 70518-2645; 71335-0706; 50228-322; 63629-8283; 70518-2697; 43063-202; 0115-9940; 55111-221; 59917-079; 69918-370; 42291-369; 0115-1527; 50090-5567; 0173-0758; 51672-4140; 53747-016; 70518-2716; 70518-1908; 55111-226; 55154-2065; 58437-019; 60760-474; 68788-7871; 13668-045; 0173-0774; 0228-1453; 13668-049; 17511-103; 68382-009; 65841-683; 14799-2011; 68382-981; 0615-8150; 68382-980; 53296-0059; 16714-703; 16714-624; 0173-0633; 0395-8217; 0173-0760; 55111-717; 69097-149; 65862-361; 68382-982; 12666-0005; 67877-164; 16714-627; 69918-380; 72888-025; 65841-684; 0904-7007; 42291-446; 65862-266; 70518-3139; 66406-0284; 50090-2130; 58437-020; 49884-881; 63187-487; 72189-063; 13668-341; 68788-7223; 0228-1435; 13668-266; 71335-1110; 0115-9941; 16714-702; 0115-9942; 70518-1479; 50090-4939; 55111-223; 51672-4130; 70518-2889; 62332-040; 68788-7168; 69918-350; 0173-0642; 63629-4697; 0173-0781; 71335-0044; 69102-150; 50090-3914; 55154-2331; 62332-096; 62332-039; 16714-195; 51407-060; 53104-7606; 59746-248; 65162-990; 71205-245; 11014-0157; 0173-0755; 16714-194; 69102-300; 49884-882; 70518-3187; 0173-0778; 0228-1410; 66406-0282; 65162-988; 65841-685; 0115-9939; 50090-5828; 13668-340; 62331-047; 72888-026; 68382-983; 51407-061; 13668-048; 27241-185; 55111-220; 65862-230; 64679-273; 62332-095; 68382-109; 0228-1580; 60760-050; 49884-484; 42291-368; 49711-0111; 16714-626; 0173-0759; 43598-550; 69102-306; 49884-880; 53002-1513; 64679-272; 43598-553; 68022-7036; 59285-023; 68382-984; 0173-0777; 50090-2129; 64679-271; 58437-024; 68462-229; 0228-1638; 67877-167; 43598-552; 16714-625; 0173-0757; 59917-080; 58118-1111; 71335-1179; 65162-949; 0173-0756; 66406-0283; 71335-1579; 49884-485; 70518-3043; 0115-1526; 16714-197; 68382-008; 13668-339; 65162-956; 0228-1422; 69102-639; 50228-321; 53002-2513; 59746-245; 13668-047; 68084-319; 46708-275; 42291-366; 42419-012; 0173-0527; 0173-0761; 65162-958; 50090-5827; 46708-277; 0173-0780; 70518-2503; 55700-626; 29300-111; 16571-786; 65841-690; 68382-007; 42291-444; 51672-4131; 68084-318; 0115-1528; 70518-1978; 42291-448; 69102-320; 50090-2131; 0615-7975; 0173-0772; 43063-203; 50090-5850; 55111-225; 29300-113; 68788-7647; 11014-0154; 42291-445; 70518-2755; 42291-367; 0173-0594; 11014-0156
Synonyms Lamotrigine | 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine | 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine | Lamictal | Crisomet | Lamiktal | BW-430C | BW 430C | BW430C | Labileno
Chemical Information
Molecular Formula C9H7Cl2N5
CAS Registry Number 84057-84-1
SMILES C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.0040.009409%
Atelectasis22.01.02.0010.000902%
Atopy10.01.04.0050.000516%Not Available
Atrial fibrillation02.03.03.002--
Atrial septal defect03.07.02.002; 02.04.02.0090.009022%Not Available
Atrioventricular block02.03.01.0020.000387%Not Available
Atrioventricular block complete02.03.01.0030.000902%
Attention deficit/hyperactivity disorder19.21.04.0010.003995%Not Available
Aura17.02.07.0110.000644%Not Available
Autism17.03.05.001; 19.22.02.0010.000516%Not Available
Back disorder15.03.01.0140.000387%Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Beta 2 microglobulin increased13.09.01.0150.000387%Not Available
Beta 2 microglobulin urine increased13.09.01.0160.000258%Not Available
Bipolar I disorder19.16.01.0020.000258%Not Available
Bladder pain20.02.02.001--Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blindness06.02.02.001; 17.17.01.0030.001031%Not Available
Blister23.03.01.001; 12.01.06.0020.009409%Not Available
Blood albumin decreased13.09.01.0010.000644%Not Available
Blood bilirubin increased13.03.01.0080.002062%
Blood calcium decreased13.11.01.0020.000516%Not Available
Blood chloride decreased13.11.01.0040.000258%Not Available
Blood creatine phosphokinase increased13.04.01.0010.003222%
Blood creatinine increased13.13.01.0040.003480%
Blood fibrinogen decreased13.01.02.0030.000387%
Blood glucose decreased13.02.02.0010.000387%Not Available
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