Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lamotrigine
Drug ID BADD_D01243
Description Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It is approved for use in more than 30 countries.[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. While it is indicated for epilepsy and bipolar disorders, there is evidence that lamotrigine could have some clinical efficacy in certain neuropathic pain states.[A849,A850]
Indications and Usage Indicated for the maintenance treatment of Bipolar I Disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in adults (≥18 years of age) treated for acute mood episodes with standard therapy [FDA Label].
Marketing Status Prescription; Discontinued
ATC Code N03AX09
DrugBank ID DB00555
KEGG ID D00354
MeSH ID D000077213
PubChem ID 3878
TTD Drug ID D03FLC
NDC Product Code 29300-114; 13668-342; 0173-0779; 69102-312; 58437-021; 50228-319; 62332-038; 67835-0016; 68462-228; 55111-222; 61919-802; 65841-686; 69102-359; 51672-4139; 58437-023; 67877-166; 55700-683; 0173-0526; 59746-247; 65162-986; 50228-320; 0173-0699; 51407-062; 68382-006; 71335-1469; 0904-7008; 0115-1529; 65841-682; 68788-7544; 46708-276; 69102-137; 16714-893; 55111-720; 16714-700; 64679-275; 55111-043; 16714-701; 55289-410; 42291-443; 70518-1523; 53002-1512; 65862-362; 65015-626; 65841-687; 70518-2406; 65862-227; 69102-319; 43063-259; 59917-077; 42291-447; 68788-6868; 69097-148; 67877-165; 0173-0643; 70518-3109; 68382-010; 63187-744; 61919-534; 49884-487; 49884-486; 55111-428; 66406-0281; 60760-549; 68382-979; 0615-8267; 69097-152; 51927-0021; 29300-112; 43063-238; 71335-1919; 43598-551; 59917-078; 27241-183; 72888-028; 51407-063; 16714-196; 53002-2512; 70518-2535; 11014-0155; 27241-184; 76420-182; 0173-0776; 12658-0579; 72888-027; 70518-3150; 46708-274; 68382-108; 0615-7964; 69097-151; 65862-229; 55154-2330; 51672-4132; 59746-246; 46708-853; 65372-1103; 68382-011; 27241-186; 65862-228; 69918-360; 0173-0817; 58118-2148; 0173-0644; 72789-206; 12658-0578; 16714-623; 71335-1748; 70518-2563; 58437-022; 65841-689; 0173-0754; 71335-0830; 55111-718; 64679-274; 62332-037; 70518-2577; 51552-1361; 16571-785; 51672-4133; 55111-419; 55111-719; 69102-301; 70518-2645; 71335-0706; 50228-322; 63629-8283; 70518-2697; 43063-202; 0115-9940; 55111-221; 59917-079; 69918-370; 42291-369; 0115-1527; 50090-5567; 0173-0758; 51672-4140; 53747-016; 70518-2716; 70518-1908; 55111-226; 55154-2065; 58437-019; 60760-474; 68788-7871; 13668-045; 0173-0774; 0228-1453; 13668-049; 17511-103; 68382-009; 65841-683; 14799-2011; 68382-981; 0615-8150; 68382-980; 53296-0059; 16714-703; 16714-624; 0173-0633; 0395-8217; 0173-0760; 55111-717; 69097-149; 65862-361; 68382-982; 12666-0005; 67877-164; 16714-627; 69918-380; 72888-025; 65841-684; 0904-7007; 42291-446; 65862-266; 70518-3139; 66406-0284; 50090-2130; 58437-020; 49884-881; 63187-487; 72189-063; 13668-341; 68788-7223; 0228-1435; 13668-266; 71335-1110; 0115-9941; 16714-702; 0115-9942; 70518-1479; 50090-4939; 55111-223; 51672-4130; 70518-2889; 62332-040; 68788-7168; 69918-350; 0173-0642; 63629-4697; 0173-0781; 71335-0044; 69102-150; 50090-3914; 55154-2331; 62332-096; 62332-039; 16714-195; 51407-060; 53104-7606; 59746-248; 65162-990; 71205-245; 11014-0157; 0173-0755; 16714-194; 69102-300; 49884-882; 70518-3187; 0173-0778; 0228-1410; 66406-0282; 65162-988; 65841-685; 0115-9939; 50090-5828; 13668-340; 62331-047; 72888-026; 68382-983; 51407-061; 13668-048; 27241-185; 55111-220; 65862-230; 64679-273; 62332-095; 68382-109; 0228-1580; 60760-050; 49884-484; 42291-368; 49711-0111; 16714-626; 0173-0759; 43598-550; 69102-306; 49884-880; 53002-1513; 64679-272; 43598-553; 68022-7036; 59285-023; 68382-984; 0173-0777; 50090-2129; 64679-271; 58437-024; 68462-229; 0228-1638; 67877-167; 43598-552; 16714-625; 0173-0757; 59917-080; 58118-1111; 71335-1179; 65162-949; 0173-0756; 66406-0283; 71335-1579; 49884-485; 70518-3043; 0115-1526; 16714-197; 68382-008; 13668-339; 65162-956; 0228-1422; 69102-639; 50228-321; 53002-2513; 59746-245; 13668-047; 68084-319; 46708-275; 42291-366; 42419-012; 0173-0527; 0173-0761; 65162-958; 50090-5827; 46708-277; 0173-0780; 70518-2503; 55700-626; 29300-111; 16571-786; 65841-690; 68382-007; 42291-444; 51672-4131; 68084-318; 0115-1528; 70518-1978; 42291-448; 69102-320; 50090-2131; 0615-7975; 0173-0772; 43063-203; 50090-5850; 55111-225; 29300-113; 68788-7647; 11014-0154; 42291-445; 70518-2755; 42291-367; 0173-0594; 11014-0156
Synonyms Lamotrigine | 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine | 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine | Lamictal | Crisomet | Lamiktal | BW-430C | BW 430C | BW430C | Labileno
Chemical Information
Molecular Formula C9H7Cl2N5
CAS Registry Number 84057-84-1
SMILES C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gingival hyperplasia07.09.03.0020.000258%Not Available
Gingival pain07.09.04.0010.000258%
Gingivitis11.01.04.013; 07.09.03.003--
Glaucoma06.03.01.002--
Glossitis07.14.01.0010.000258%Not Available
Glossodynia07.14.02.0010.000902%Not Available
Goitre05.02.01.001; 14.11.01.008--Not Available
Graft versus host disease12.02.09.001; 10.02.01.0270.000067%Not Available
Granulocytopenia01.02.03.003--Not Available
Haemangioma24.03.06.004; 16.02.01.0020.001418%Not Available
Haemangioma congenital24.03.06.005; 16.02.01.004; 03.07.03.0020.000773%Not Available
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematocrit decreased13.01.05.001--Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.002--Not Available
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemolysis01.06.04.0020.000644%
Haemolytic anaemia01.06.03.002--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Haemorrhage subcutaneous24.07.06.010; 23.06.07.0020.000773%Not Available
Haemothorax22.05.02.001; 12.01.03.002; 24.07.01.0080.001031%
Hair colour changes23.02.06.0010.000258%
Hallucination19.10.02.0020.003738%
Hallucination, auditory19.10.02.0030.001031%Not Available
Hallucination, tactile19.10.02.0080.000258%Not Available
Hallucination, visual19.10.02.0040.001160%Not Available
Hallucinations, mixed19.10.02.0070.000516%Not Available
Headache17.14.01.0010.018173%
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