| Pharmaceutical Information |
| Drug Name |
Ketotifen |
| Drug ID |
BADD_D01234 |
| Description |
Ketotifen is a benzocycloheptathiophene derivative[A231204] with potent antihistaminic and mast cell stabilizing properties. It has a similar structure to some other first-generation antihistamines such as [cyproheptadine] and [azatadine].[A231204]
Ketotifen was first developed in Switzerland in 1970 by Sandoz Pharmaceuticals and was initially marketed for the treatment of anaphylaxis.[A231204] In the US, it is now used in an over-the-counter ophthalmic formulation for the treatment of itchy eyes associated with allergies,[L32278] and in Canada a prescription-only oral formulation is available and indicated as an add-on therapy for children with atopic asthma.[L32283] In addition, oral ketotifen is used in Mexico and across Europe for the treatment of various allergic symptoms and disorders,[A231204] including urticaria, mastocytosis, and food allergy. |
| Indications and Usage |
Indicated as an add-on or prophylactic oral medication in the chronic treatment of mild atopic asthmatic children. Also used as self-medication for the temporary relief of itching of the eye due to allergic conjunctivitis (ophthalmic). |
| Marketing Status |
OTC; Discontinued |
| ATC Code |
R06AX17; S01GX08 |
| DrugBank ID |
DB00920
|
| KEGG ID |
D08105
|
| MeSH ID |
D007665
|
| PubChem ID |
3827
|
| TTD Drug ID |
D0YG7M
|
| NDC Product Code |
Not Available |
| Synonyms |
Ketotifen | Ketotiphene | Ketotiphen | 4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one | Ketotifene | Zaditen | Ketotifen Fumarate | Fumarate, Ketotifen |
|
| Chemical Information |
| Molecular Formula |
C19H19NOS |
| CAS Registry Number |
34580-13-7 |
| SMILES |
CN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1 |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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