Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketorolac tromethamine
Drug ID BADD_D01233
Description Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.[L6358][L6508][L11055][L3674][L11070] It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis.[L6520] Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.[L6511]
Indications and Usage For the short-term (~5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting.
Marketing Status Prescription; Discontinued
ATC Code M01AB15; S01BC05
DrugBank ID DB00465
KEGG ID D00813
MeSH ID D020911
PubChem ID 84003
TTD Drug ID Not Available
NDC Product Code 70518-2927; 0023-2181; 25021-700; 71205-582; 35356-696; 72611-719; 0404-9952; 60687-104; 0409-3796; 60505-1003; 0023-9277; 0338-0076; 71872-7212; 63278-1056; 68083-132; 51662-1488; 35573-450; 50090-2746; 0409-3795; 0404-9884; 50090-4635; 50090-5428; 71205-594; 63323-162; 70518-3308; 45865-613; 71872-7118; 70860-701; 70529-119; 0487-6232; 0404-9883; 50090-4583; 51655-170; 69344-144; 55154-0120; 63323-161; 71872-7234; 72266-119; 68788-8149; 0338-0072; 71872-7132; 61919-138; 66267-418; 63629-2488; 71872-7131; 65862-775; 55150-340; 50090-5013; 70529-121; 70529-120; 80425-0139; 60760-314; 12711-5990; 71872-7213; 62991-2818; 68083-103; 25021-701; 55154-1555; 66993-193; 50090-2762; 68083-134; 76420-250; 72189-335; 71872-7119; 0395-8216; 71872-7022; 43235-0001; 55289-328; 42571-137; 0641-6043; 68071-1787; 55154-9366; 52584-725; 64679-758; 0093-0314; 0641-6041; 55154-9368; 72611-725; 71205-116; 71335-1904; 17478-207; 55154-6960; 69543-388; 71872-7185; 70860-700; 68071-2576; 53069-0620; 14501-0010; 67296-1412; 0641-6042; 76045-107; 0338-0069; 50090-3397; 72189-054; 55154-1556; 68083-104; 72611-722; 68071-2443; 64679-757; 47335-221; 63187-628; 72266-118; 51662-1295; 0409-3793; 55150-341; 50090-3364; 70518-0048; 66267-832; 71872-7188; 51927-0111; 71335-1803; 76045-209; 53002-6990; 63187-128; 51552-1371; 53002-7780; 76420-032; 51927-3443; 76045-104; 70518-2610; 60758-773; 49452-3926; 66577-045; 55154-9398; 63629-2974; 49711-0103; 42291-358; 50090-5609; 0023-3507; 68071-4811; 61314-126; 50090-0601; 55150-339; 66022-0117; 70529-122; 43063-904; 65044-7424; 55111-014; 49452-3919; 76420-252; 71205-296; 68788-7517; 51662-1292; 68071-2400; 47335-219; 47335-220; 38779-2249; 52584-722; 70518-3369; 0378-1134; 66577-016; 68083-133; 68071-2569; 17478-209; 50090-3550; 52584-719; 63187-777; 76045-105; 76420-184; 65862-770; 17478-208; 68071-2252
Synonyms Ketorolac Tromethamine | Acular | Toradol
Chemical Information
Molecular Formula C19H24N2O6
CAS Registry Number 74103-07-4
SMILES C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
Bleeding time prolonged13.01.02.002--Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blood creatinine increased13.13.01.004--
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
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