Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status Prescription; Discontinued
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 49452-3917; 68981-031; 82348-102; 0276-0504; 12660-0006; 69336-127; 12854-516; 43235-0010; 63275-9996; 51927-0057; 76465-0001; 51927-0025; 51552-0307; 63187-018; 38779-0078; 51927-0231; 0395-8056; 45865-485; 38779-3039; 49452-3924; 0378-8200; 79572-019; 51604-0011
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Gastrointestinal toxicityTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Gastrointestinal toxicityGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Linear IgA disease23.03.01.015; 10.04.02.0060.012417%Not Available
Lip oedema23.04.01.006; 10.01.05.004; 07.05.04.0040.037250%Not Available
Loss of consciousness17.02.04.0040.016556%Not Available
Lung abscess11.01.09.006; 22.07.01.0060.008278%Not Available
Malaise08.01.01.003--
Mediastinitis22.09.03.002; 11.01.08.0270.012417%
Melaena24.07.02.013; 07.12.02.0040.057945%Not Available
Meningitis aseptic17.06.03.002; 11.01.03.002--Not Available
Menometrorrhagia21.01.03.001--Not Available
Metabolic acidosis14.01.01.0030.005399%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Miosis17.02.11.002; 06.05.03.0030.016556%Not Available
Mouth ulceration07.05.06.004--Not Available
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.0010.066223%
Necrosis24.04.02.006; 08.03.03.001--Not Available
Necrotising fasciitis15.03.03.004; 11.01.17.0020.005399%Not Available
Nephrotic syndrome20.05.01.002--
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Oedema14.05.06.010; 08.01.07.0060.024834%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.024834%
Oesophagitis07.08.05.0010.008278%
Onycholysis23.02.05.004--Not Available
Pain08.01.08.004--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.008278%Not Available
Palpitations02.01.02.0030.008278%
Pancreatitis07.18.01.0010.008278%
Pancreatitis acute07.18.01.0020.016556%Not Available
The 5th Page    First    Pre   5 6 7 8 9    Next   Last    Total 9 Pages