Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ixazomib
Drug ID BADD_D01223
Description Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortezomib (the first PI approved for multiple myeloma therapy) in the control of myeloma growth and prevention of bone loss. Ixazomib citrate is marketed by Takeda Pharmaceuticals under the brand name Ninlaro, which is a prodrug that becomes quickly converted to its active metabolite, ixazomib, after administration.
Indications and Usage Ixazomib is indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least one prior therapy.
Marketing Status Prescription
ATC Code L01XG03
DrugBank ID DB09570
KEGG ID D10130
MeSH ID C548400
PubChem ID 25183872
TTD Drug ID Not Available
NDC Product Code 63020-230; 63020-080; 63020-079; 63020-078; 63020-390; 63020-400
Synonyms ixazomib | MLN 9708 | MLN9708 | MLN-9708 | Ninlaro
Chemical Information
Molecular Formula C14H19BCl2N2O4
CAS Registry Number 1072833-77-2
SMILES B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal disorder20.01.02.0020.001865%Not Available
Renal failure20.01.03.005--Not Available
Renal pain20.02.03.0030.000533%Not Available
Respiratory distress22.02.01.0120.000799%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retching07.01.07.0020.000799%Not Available
Rib fracture15.08.07.001; 12.04.07.0010.000533%Not Available
Sepsis11.01.11.0030.000973%
Sinusitis22.07.03.007; 11.01.13.0050.001598%
Skin disorder23.03.03.0070.000533%Not Available
Skin exfoliation23.03.07.003--Not Available
Skin reaction23.03.03.013; 10.01.03.019--Not Available
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.000533%
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome23.03.01.007; 12.03.01.014; 11.07.01.005; 10.01.03.020--
Stomatitis07.05.06.005--
Swelling08.01.03.0150.001598%Not Available
Swelling face10.01.05.018; 23.04.01.018--Not Available
Thrombocytopenia01.08.01.0020.004263%Not Available
Thrombosis24.01.01.006--Not Available
Thrombotic thrombocytopenic purpura24.07.06.014; 23.06.01.011; 01.08.01.005--
Tooth disorder07.09.05.0010.000533%Not Available
Toothache07.09.06.0010.000799%
Transient ischaemic attack24.04.06.005; 17.08.04.001--
Tremor17.01.06.002--
Tumour lysis syndrome16.32.03.002; 14.05.01.004--
Upper respiratory tract infection22.07.03.011; 11.01.13.0090.002131%
Urinary tract infection11.01.14.004; 20.08.02.001--
Urticaria23.04.02.001; 10.01.06.001--
Vertigo04.04.01.003; 17.02.12.002--
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