| Drug Name |
Isosorbide mononitrate |
| Drug ID |
BADD_D01211 |
| Description |
Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Like other organic nitrates, isosorbide mononitrate acts as a prodrug for its active metabolite, [nitric oxide], which mediates the therapeutic action of isosorbide mononitrate.[L11743] Isosorbide mononitrate has a longer duration of action than [nitroglycerin] due to its slow onset of absorption and metabolism.[T28]
First approved by the FDA in 1991,[L11743] isosorbide mononitrate is used for the prevention and management of angina pectoris caused by coronary artery disease; however, the onset of action of orally-administered isosorbide mononitrate is not rapid enough to offset an acute anginal episode.[L11698] It is available in oral tablets generically and under the brand name ISMO and Monoket. The extended-release forms of the drug are also available generically and under the brand name Imdur.[L11743] |
| Indications and Usage |
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
C01DA14 |
| DrugBank ID |
DB01020
|
| KEGG ID |
D00630
|
| MeSH ID |
C030397
|
| PubChem ID |
27661
|
| TTD Drug ID |
D0YS7D
|
| NDC Product Code |
71335-0037; 68071-3081; 70518-2207; 71335-1117; 71610-338; 0228-2620; 0228-2631; 50090-5572; 62175-106; 62175-362; 62175-107; 55154-4786; 0615-7768; 50268-453; 43353-917; 70518-2000; 62175-129; 51407-210; 42677-113; 55154-7292; 62175-119; 13668-105; 0904-6450; 51407-208; 70518-2122; 55154-4785; 71610-337; 0615-8043; 70518-2206; 70518-3081; 55154-7291; 63629-1823; 67544-224; 70518-2201; 23155-519; 70518-1485; 23155-178; 51407-209; 50742-175; 50090-5686; 23155-628; 50268-451; 0615-8044; 13668-104; 70518-2692; 63629-1424; 68382-651; 50742-177; 62175-128; 68084-592; 53002-1570; 68071-4390; 50090-4047; 13668-106; 62175-361; 63187-700; 0615-7767; 42677-101; 50742-176; 42677-102; 0904-6449; 68071-4689; 68071-4290; 68382-652; 43063-313; 70518-3132; 67544-236; 71610-321; 68084-591; 63187-900; 50090-4009; 70518-2956; 68382-650; 50268-452 |
| Synonyms |
isosorbide-5-mononitrate | isosorbide mononitrate | monocinque | 5-ISMN | isosorbide-5-nitrate | Elantan | Imdur | Ismo | Olicard-retard | Mono Mac 50D | Monoket | Mononit | Olicard 40 | 5-ISMN Durules | Monizid |
