Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isosorbide
Drug ID BADD_D01209
Description Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Indications and Usage
Marketing Status Discontinued
ATC Code Not Available
DrugBank ID DB09401
KEGG ID D00347
MeSH ID D007547
PubChem ID 12597
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Isosorbide | Dianhydrosorbitol
Chemical Information
Molecular Formula C6H10O4
CAS Registry Number 652-67-5
SMILES C1C(C2C(O1)C(CO2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Skin ulcer24.04.03.007; 23.07.03.003--
Somnolence17.02.04.006; 19.02.05.003--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tendon disorder15.07.01.002--Not Available
Tension19.06.02.005--Not Available
Thirst08.01.09.021; 14.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Torticollis17.01.03.003; 15.05.04.003--Not Available
Tremor17.01.06.002--
Tympanic membrane perforation12.01.14.001; 04.05.04.001--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Urethral disorder20.07.01.002--Not Available
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Varicose vein24.10.04.001--Not Available
Vascular purpura01.01.04.007; 24.07.06.011; 23.06.01.008--Not Available
Ventricular tachycardia02.03.04.010--
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Withdrawal hypertension24.08.02.009; 08.06.02.007--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Epigastric discomfort07.01.02.004--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Haemorrhage24.07.01.002--Not Available
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