Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isosorbide
Drug ID BADD_D01209
Description Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Indications and Usage Isosorbide was previously indicated for temporary reduction of intraocular pressure and used to interrupt an acute glaucoma attack, however, this is not a currently approved indication.[L34064] Refer to [isosorbide mononitrate] and [isosorbide dinitrate] drug entries for more isosorbide indications.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB09401
KEGG ID D00347
MeSH ID D007547
PubChem ID 12597
TTD Drug ID Not Available
NDC Product Code Not Available
UNII WXR179L51S
Synonyms Isosorbide | Dianhydrosorbitol
Chemical Information
Molecular Formula C6H10O4
CAS Registry Number 652-67-5
SMILES C1C(C2C(O1)C(CO2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Amblyopia06.02.01.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrial fibrillation02.03.03.002--
Atrophic vulvovaginitis21.02.01.003--Not Available
Back pain15.03.04.005--
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block02.03.01.009--Not Available
Cardiac failure02.05.01.001--
Cardiac murmur13.14.01.001--Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.009--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
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