Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isosorbide
Drug ID BADD_D01209
Description Isosorbide was previously available in an oral formulation for the reduction of intraocular pressure. It was approved by the FDA in 1980, but has since been discontinued. Currently, isosorbide is an organic nitrate currently available in the [isosorbide mononitrate] and [isosorbide dinitrate] forms, and is used for the prevention of angina. Refer to these drug entries for more information.
Indications and Usage
Marketing Status Discontinued
ATC Code Not Available
DrugBank ID DB09401
KEGG ID D00347
MeSH ID D007547
PubChem ID 12597
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Isosorbide | Dianhydrosorbitol
Chemical Information
Molecular Formula C6H10O4
CAS Registry Number 652-67-5
SMILES C1C(C2C(O1)C(CO2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Acne23.02.01.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Amblyopia06.02.01.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Atrial fibrillation02.03.03.002--
Atrophic vulvovaginitis21.02.01.003--Not Available
Back pain15.03.04.005--
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Breast pain21.05.05.003--
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block02.03.01.009--Not Available
Cardiac failure02.05.01.001--
Cardiac murmur13.14.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
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