Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iron sucrose
Drug ID BADD_D01199
Description Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease patients.
Indications and Usage Iron sucrose is elemental iron as an injection. It replenishes body iron stores in patients with iron deficiency.
Marketing Status Prescription; Discontinued
ATC Code B03AB02
DrugBank ID DB09146
KEGG ID D04616
MeSH ID D000077605
PubChem ID 91663255
TTD Drug ID D0M4OC
NDC Product Code 50090-4541; 0517-2325; 66022-0119; 0517-2340; 55111-974; 0517-2310; 49230-530; 76055-1001; 59353-652; 49230-534
Synonyms Ferric Oxide, Saccharated | Saccharated Ferric Oxide | Ferric Saccharate | D-Glucaric acid, iron(2+) salt (1:1) | Iron Sucrose | Iron-Saccharate | Iron Saccharate | Ferri-Saccharate | Ferri Saccharate | Iron Oxide (Saccharated) | Iron(III)-Hydroxide Sucrose Complex | Venofer | Hippiron
Chemical Information
Molecular Formula C12H29Fe5Na2O23
CAS Registry Number 8047-67-4
SMILES C(C1C(C(C(C(O1)OC2(C(C(C(O2)CO)O)O)CO)O)O)O)O.O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2 ].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site reaction12.07.03.015; 08.02.03.014--
Iron deficiency14.13.02.002--Not Available
Joint stiffness15.01.02.0030.004165%Not Available
Joint swelling15.01.02.0040.010829%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.002499%
Leukocytosis01.02.01.0020.001666%
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.002499%Not Available
Local swelling08.01.03.0130.005831%Not Available
Loss of consciousness17.02.04.0040.026657%Not Available
Malaise08.01.01.0030.041651%
Memory impairment19.20.01.003; 17.03.02.003--
Metabolic acidosis14.01.01.0030.004165%Not Available
Microcytosis01.07.02.0050.001666%Not Available
Muscle spasms15.05.03.0040.008330%
Muscular weakness15.05.06.001; 17.05.03.005--
Musculoskeletal pain15.03.04.0070.001666%
Myalgia15.05.02.0010.009163%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.0010.064143%
Neck pain15.03.04.0090.003332%
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.001666%Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.0060.004998%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.024158%
Osteomalacia20.01.01.002; 15.02.03.001; 14.04.04.0010.001666%Not Available
Oxygen saturation decreased13.02.01.0040.003332%Not Available
Pain08.01.08.0040.019992%
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