Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Irinotecan hydrochloride
Drug ID BADD_D01196
Description Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
Indications and Usage For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
Marketing Status Prescription; Discontinued
ATC Code L01CE02
DrugBank ID DB00762
KEGG ID D01061
MeSH ID D000077146
PubChem ID 74990
TTD Drug ID D07HOB
NDC Product Code 0143-9583; 72485-211; 67184-0511; 45963-614; 67184-0513; 55150-352; 0009-7529; 17337-0307; 65129-1025; 16714-027; 68083-382; 25021-230; 59923-714; 63323-193; 16714-131; 59923-702; 70700-170; 57884-0009; 72485-213; 61703-349; 59923-715; 59923-716; 55150-354; 50742-401; 72485-212; 50742-402; 61200-112; 0143-9701; 15054-0043; 14778-1111; 55150-353; 12780-4860; 60505-6128; 67184-0014; 0143-9702; 67184-0512
Synonyms Irinotecan | Irrinotecan | Camptothecin-11 | Camptothecin 11 | SN 38 11 | SN-38-11 | SN3811 | SN 38 | SN-38 | NK012 Compound | CPT-11 | CPT11 | CPT 11 | Camptosar | 7-Ethyl-10-hydroxycamptothecin | 7 Ethyl 10 hydroxycamptothecin | Irinotecan Hydrochloride
Chemical Information
Molecular Formula C33H39ClN4O6
CAS Registry Number 100286-90-6
SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC 7.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCocaine esteraseO00748Not AvailableNot Available
ApoptosisDNA topoisomerase 1P11387T09826Not Available
Bone marrow failureThiopurine S-methyltransferaseP51580Not AvailableNot Available
Cytogenetic investigationsDNA topoisomerase 1P11387T09826Not Available
DiarrhoeaThiopurine S-methyltransferaseP51580Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder19.19.02.002; 17.02.08.003; 22.02.05.034--Not Available
Stomatitis07.05.06.005--
Sudden death08.04.01.003; 02.03.04.013--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Thrombosis24.01.01.006--Not Available
Tumour lysis syndrome16.32.03.002; 14.05.01.004--
Ulcer08.03.06.001--Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Vertigo17.02.12.002; 04.04.01.003--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Hand and foot syndrome secondary to sickle cell anaemia23.07.04.011; 01.04.02.003--Not Available
Neutropenic sepsis11.01.11.006; 01.02.03.007--Not Available
Lung cancer metastatic16.19.02.003; 22.08.01.004--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Gastrointestinal hypermotility07.02.04.005--Not Available
Transaminases increased13.03.01.015--Not Available
Hepatic cancer metastatic16.07.02.002; 09.04.02.006--Not Available
Haemorrhage24.07.01.002--Not Available
Blood bilirubin abnormal13.03.01.016--Not Available
Vasodilation procedure25.03.01.001--Not Available
Angiopathy24.03.02.007--Not Available
Neutropenic infection11.01.08.024; 01.02.03.009--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Neurological symptom17.02.05.010--Not Available
Cardiac disorder02.01.01.003--Not Available
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