Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ipratropium bromide
Drug ID BADD_D01192
Description Ipratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic agent.[A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption.[A176957] Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its first monotherapy product was FDA approved in 1986, while the combination product of ipratropium and [albuterol] was approved in 1996.[L5894, L5891]
Indications and Usage For maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.
Marketing Status Prescription; Discontinued
ATC Code R01AX03; R03BB01
DrugBank ID DB00332
KEGG ID D02212
MeSH ID D009241
PubChem ID 657308
TTD Drug ID D0S0AS
NDC Product Code 60687-394; 0591-3798; 53104-7704; 0597-0087; 60505-0826; 50090-0961; 76204-100; 53002-8410; 0378-7970; 55154-4351; 15308-1001; 16714-526; 12714-049; 0487-9801; 50090-0668; 68071-1737; 49452-3791; 66412-0753; 24208-398; 51552-1500; 24208-399; 50090-4185; 63187-188; 65862-905; 58032-0100; 70518-2874; 43235-0013; 52221-108; 59349-0013; 16714-527; 0054-0045; 0054-0046; 47335-706; 43898-0102; 70518-1070; 60505-0827
Synonyms Ipratropium | (endo,syn)-(+-)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane | N-Isopropylatropine | N Isopropylatropine | Atrovent | Ipratropium Bromide Anhydrous | Ipratropium Bromide, (endo,anti)-Isomer | Sch-1178 | Sch 1178 | Sch1178 | Ipratropium Bromide Monohydrate | Ipratropium Bromide, endo-Isomer | Itrop | Sch-1000 | Sch 1000 | Sch1000 | Ipratropium Bromide | Ipratropium Bromide, (exo,syn)-Isomer
Chemical Information
Molecular Formula C20H30BrNO3
CAS Registry Number 22254-24-6
SMILES CC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Wheezing22.03.01.009--
Conjunctival hyperaemia06.04.01.004--Not Available
Nasal discomfort22.02.05.020--Not Available
Gastrointestinal motility disorder07.02.03.001--Not Available
Respiratory tract infection22.07.07.001; 11.01.08.017--Not Available
Upper-airway cough syndrome22.02.05.030--
Nasal pruritus22.04.03.018--Not Available
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