Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ioxaglic acid
Drug ID BADD_D01188
Description Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during angiography, arteriography, arthrography, cholangiography, urography, and computed tomography [L1889]. Ioxaglic acid has a low osmolarity and is associated with fewer side effects compared to older contrast agents [L1883].
Indications and Usage This medicinal product is for diagnostic use only in adults and children as a low-osmolality medium [L1883], [A7924].
Marketing Status Discontinued
ATC Code V08AB03
DrugBank ID DB09313
KEGG ID D01761
MeSH ID D007485
PubChem ID 3742
TTD Drug ID D0X7IT
NDC Product Code Not Available
Synonyms Ioxaglic Acid | Ioxaglate Meglumine | Meglumine, Ioxaglate | Methylglucamine Ioxaglate | Ioxaglate, Methylglucamine | Hexabrix | Ioxaglic Acid, Calcium Salt (2:1) | P-286 (Contrast Media) | P286 (Contrast Media) | Ioxaglate | Ioxaglate Sodium | Ioxaglic Acid Monosodium Salt
Chemical Information
Molecular Formula C24H21I6N5O8
CAS Registry Number 59017-64-0
SMILES CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I) C(=O)NC)I
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Arteriosclerosis24.04.02.001--Not Available
Arthralgia15.01.02.001--
Asthma22.03.01.002; 10.01.03.010--Not Available
Blood pressure fluctuation24.06.01.002--Not Available
Body temperature increased13.15.01.001--Not Available
Brachial plexus injury17.09.03.006; 12.01.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Cough22.02.03.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disseminated intravascular coagulation24.01.01.010; 01.01.02.002--
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