Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ioxaglate meglumine
Drug ID BADD_D01187
Description Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opaque in its appearance on x-ray film, improving the visualization of important structures and organs during angiography, arteriography, arthrography, cholangiography, urography, and computed tomography [L1889]. Ioxaglic acid has a low osmolarity and is associated with fewer side effects compared to older contrast agents [L1883].
Indications and Usage This medicinal product is for diagnostic use only in adults and children as a low-osmolality medium [L1883], [A7924].
Marketing Status Discontinued
ATC Code V08AB03
DrugBank ID DB09313
KEGG ID D04598
MeSH ID D007485
PubChem ID 20055342
TTD Drug ID D0X7IT
NDC Product Code Not Available
Synonyms Ioxaglic Acid | Ioxaglate Meglumine | Meglumine, Ioxaglate | Methylglucamine Ioxaglate | Ioxaglate, Methylglucamine | Hexabrix | Ioxaglic Acid, Calcium Salt (2:1) | P-286 (Contrast Media) | P286 (Contrast Media) | Ioxaglate | Ioxaglate Sodium | Ioxaglic Acid Monosodium Salt
Chemical Information
Molecular Formula C31H38I6N6O13
CAS Registry Number 59018-13-2
SMILES CC(=O)N(C)C1=C(C(=C(C(=C1I)C(=O)NCC(=O)NC2=C(C(=C(C(=C2I)C(=O)O)I)C(=O)NCCO)I)I) C(=O)NC)I.CNCC(C(C(C(CO)O)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angioedema10.01.05.009; 23.04.01.001--Not Available
Aphasia19.21.01.001; 17.02.03.001--
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chills08.01.09.001; 15.05.03.016--
Choking22.02.05.001--Not Available
Coma17.02.09.001--Not Available
Cough22.02.03.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Death08.04.01.001--
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis23.06.01.001; 01.01.03.001; 24.07.06.002--Not Available
Erythema23.03.06.001--Not Available
Extravasation08.01.03.008--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Flushing08.01.03.025; 24.03.01.002; 23.06.05.003--
Haematoma24.07.01.001--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypoaesthesia17.02.06.023--Not Available
Laryngospasm22.04.02.002--
Loss of consciousness17.02.04.004--Not Available
Muscle spasms15.05.03.004--
Nasal congestion22.04.04.001--
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