Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iopromide
Drug ID BADD_D01182
Description Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the path of flow of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Available as the FDA-approved product Ultravist, iopromide is used in radiographic studies such as intra-arterial digital subtraction angiography (IA-DSA), cerebral and peripheral arteriography, peripheral venography, excretory urography, brain computer tomography (CT), coronary arteriography, left ventriculography, visceral angiography, and aortography.
Indications and Usage Iopromide, as the product Iovist, is indicated for use as an X-ray contrast agent in the following procedures: Intra-arterial digital subtraction angiography (IA-DSA) (150 mg I/mL) Cerebral arteriography and peripheral arteriography (300 mg I/mL) Coronary arteriography and left ventriculography, visceral angiography and aortography (370 mg I/mL) Peripheral venography (240 mg I/mL) Excretory urography (300 mg I/mL) Contrast computed tomography (CT) imaging of head and body (300 mg I/mL and 370 mg I/mL)
Marketing Status approved
ATC Code V08AB05
DrugBank ID DB09156
KEGG ID D01893
MeSH ID C038192
PubChem ID 3736
TTD Drug ID D07GNP
NDC Product Code 50419-344; 50419-346; 50419-347; 50419-348
UNII 712BAC33MZ
Synonyms iopromide | lopromid | N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N-methylisophthalamide | iopromid | Ultravist 300 | Clarograf | Ultravist
Chemical Information
Molecular Formula C18H24I3N3O8
CAS Registry Number 73334-07-3
SMILES CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lacrimal structural disorder06.06.04.013--Not Available
Language disorder19.19.01.006; 17.02.08.0150.014227%Not Available
Vascular malformation24.03.03.014; 03.07.03.004--Not Available
Mouth swelling23.04.01.020; 10.01.05.020; 07.05.04.0070.010670%Not Available
Noninfective sialoadenitis07.06.04.0030.007113%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.039124%
Anal incontinence17.05.01.021; 07.01.06.0290.035567%
Apallic syndrome17.02.04.0180.007113%Not Available
Ruptured cerebral aneurysm17.08.01.059; 24.02.04.0050.007113%Not Available
Slow response to stimuli17.02.05.0630.010670%Not Available
Laryngeal discomfort22.12.03.0090.010670%Not Available
Pharyngeal hypoaesthesia22.04.05.017; 17.02.06.0340.010670%Not Available
Binocular eye movement disorder17.02.05.052; 06.05.02.0170.007113%Not Available
Communication disorder19.19.01.0080.007113%Not Available
Foaming at mouth08.01.03.070; 07.05.05.019; 17.02.05.0560.028454%Not Available
Asthmatic crisis22.03.01.018--Not Available
Oral mucosal erythema07.05.05.0230.007113%Not Available
Tongue pruritus07.14.02.0210.038412%Not Available
Lip pruritus07.05.05.0210.043392%Not Available
Spinal pain17.10.01.020; 08.01.08.030; 15.02.01.0080.007113%Not Available
Eyelid thickening23.07.05.007; 06.06.04.0210.007113%Not Available
Vein rupture24.03.02.032; 12.01.11.0110.014227%Not Available
Hemianaesthesia17.02.06.0430.014227%Not Available
Administration site extravasation12.07.04.019; 08.02.04.0190.019206%Not Available
Contrast media allergy10.01.01.010; 12.02.05.0160.138711%Not Available
Mucosal disorder08.01.06.029--Not Available
Pharyngeal swelling22.04.05.0280.022763%Not Available
Swelling of eyelid06.04.04.018; 23.04.01.026; 10.01.05.0260.014227%Not Available
Type II hypersensitivity10.01.03.0640.007113%Not Available
The 15th Page    First    Pre   15    Total 15 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene