Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Interferon alfa-2a
Drug ID BADD_D01166
Description Interferon a (human leukocyte protein moiety reduced). A type I interferon consisting of 165 amino acid residues with lysine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes. It is used extensively as an antiviral or antineoplastic agent. An oral form is being developed by Amarillo Biosciences.
Indications and Usage For the treatment of chronic hepatitis C, hairy cell leukemia, AIDS-related Kaposi's sarcoma, and chronic myelogenous leukemia. Also for the treatment of oral warts arising from HIV infection.
Marketing Status Not Available
ATC Code L03AB04
DrugBank ID DB00034
KEGG ID D00745
MeSH ID D000077190
PubChem ID Not Available
TTD Drug ID D0P0WV
NDC Product Code Not Available
Synonyms Interferon alpha-2 | Interferon alpha 2 | Interferon-alpha 2 | Interferon alpha-A | Interferon alpha A | LeIF A | IFN-alpha 2 | IFN-alpha-2 | Interferon alfa-2a | Interferon alfa 2a | Recombinant Interferon alpha-2a | Interferon alpha-2a, Recombinant | Recombinant Interferon alpha 2a | Roferon-A | Roferon A | RoferonA | Ro 22-8181 | Ro 22 8181 | Ro 228181 | Viferon | Sch-30500 | Sch 30500 | Sch30500 | Intron A (Interferon) | Reaferon | Interferon alfa-2b | Interferon alfa 2b | Interferon alpha-2b, Recombinant | Interferon alpha 2b, Recombinant | Recombinant Interferon alpha-2b | Recombinant Interferon alpha 2b | IFNalpha-2b, Recombinant | IFNalpha 2b, Recombinant | Recombinant IFNalpha-2b
Chemical Information
Molecular Formula Not Available
CAS Registry Number 76543-88-9
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Papilloedema17.07.02.004; 06.09.02.002; 24.03.07.001--
Paraesthesia17.02.06.005--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pneumonitis22.01.01.006--
Polyarthritis15.01.01.005--Not Available
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Psoriasis23.03.14.002; 10.02.01.036--Not Available
Psychomotor hyperactivity19.11.02.003; 17.01.02.011--Not Available
Psychomotor retardation19.15.02.002--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Retinal artery thrombosis24.01.07.005; 06.10.01.007--Not Available
Retinal exudates06.10.02.003; 24.03.07.007--Not Available
Retinal haemorrhage24.07.05.003; 06.10.01.001--Not Available
Retinal ischaemia24.04.10.005; 06.10.01.009--Not Available
Retinal vein thrombosis24.01.07.002; 06.10.01.003--Not Available
Retinopathy06.10.02.001; 24.03.07.003--
Rhinitis22.07.03.006; 11.01.13.004--
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