Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Insulin (human)
Drug ID BADD_D01159
Description Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mellitus, insulin is a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions.
Indications and Usage Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.
Marketing Status Discontinued
ATC Code Not Available
DrugBank ID DB00030
KEGG ID Not Available
MeSH ID D007328
PubChem ID 118984375
TTD Drug ID D0R6CD
NDC Product Code 0002-0113; 62381-0319; 72969-034; 47918-891; 0002-0095; 0002-2510; 0002-8715; 0002-0013; 62381-0719; 0338-0126; 0002-8805; 0002-0119; 47918-902; 0002-0485; 47918-878; 0002-8824; 0002-0096; 0002-8501; 0002-9307; 62381-0509; 47918-874; 47918-880; 0002-8315; 0002-8803; 0002-2045; 0002-8215; 47918-898
Synonyms Insulin | Insulin, Regular | Regular Insulin | Soluble Insulin | Insulin, Soluble | Insulin A Chain | Sodium Insulin | Insulin, Sodium | Novolin | Iletin | Insulin B Chain | Chain, Insulin B
Chemical Information
Molecular Formula C257H383N65O77S6
CAS Registry Number 11061-68-0
SMILES CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(CSSCC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O) NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C(NC(=O)C(NC(=O)C (NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)CC(C)C)CC3=CC=C(C=C3)O)CCC(=O) N)CC(C)C)CCC(=O)O)CC(=O)N)CC4=CC=C(C=C4)O)C(=O)NC(CC(=O)N)C(=O)O)C(=O)NCC(=O)NC( CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC5=CC=CC=C5)C(=O)NC(CC6=CC=CC=C6)C(= O)NC(CC7=CC=C(C=C7)O)C(=O)NC(C(C)O)C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(C(C)O)C(=O) O)C(C)C)CC(C)C)CC9=CC=C(C=C9)O)CC(C)C)C)CCC(=O)O)C(C)C)CC(C)C)CC2=CNC=N2)CO)NC(= O)C(CC(C)C)NC(=O)C(CC2=CNC=N2)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC( =O)C(CC2=CC=CC=C2)N)C(=O)NC(C(=O)NC(C(=O)N1)CO)C(C)O)NC(=O)C(CCC(=O)N)NC(=O)C(CC C(=O)O)NC(=O)C(C(C)C)NC(=O)C(C(C)CC)NC(=O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chromosomal abnormalities and abnormal gene carriersRibosomal protein S6 kinase alpha-1Q15418T83202Not Available
HypoglycaemiaVasopressin-neurophysin 2-copeptinP01185T20975Not Available
HypoglycaemiaVasopressin V1a receptorP37288T79232Not Available
HypoglycaemiaIslet amyloid polypeptideP10997T56269Not Available
HypoglycaemiaInsulinP01308T82841Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Back pain15.03.04.005--
Blood potassium decreased13.11.01.010--Not Available
Blood pressure decreased13.14.03.002--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac failure02.05.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Coronary artery disease02.02.01.001; 24.04.04.006--Not Available
Cough22.02.03.001--
Cough decreased22.02.03.006--Not Available
Death08.04.01.001--
Depressed mood19.15.02.001--Not Available
Dermatitis23.03.04.002--Not Available
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diabetic autonomic neuropathy17.05.01.017; 14.07.04.004; 05.07.04.004--Not Available
Diabetic ketoacidosis14.07.03.001; 05.07.03.001--Not Available
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