ADReCS

Pharmaceutical Information

Drug Name	Imiquimod
Drug ID	BADD_D01142
Description	Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Indications and Usage	For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above.
Marketing Status	approved; investigational
ATC Code	D06BB10
DrugBank ID	DB00724
KEGG ID	D02500
MeSH ID	D000077271
PubChem ID	57469
TTD Drug ID	D06CTE
NDC Product Code	62350-0077; 68682-272; 72189-084; 0168-0432; 22365-121; 51672-4174; 99207-271; 66039-829; 71052-160; 64552-4008; 45802-368; 51552-1538; 62147-0087; 51672-4145; 63629-8818; 68462-536; 51927-0168; 72643-006; 0093-3133; 99207-260; 99207-270; 99207-276; 58175-0397; 62147-0072
UNII	P1QW714R7M
Synonyms	Imiquimod \| 1-Isobutyl-1H-imidazo(4,5-c)quinolin-4-amine \| S 26308 \| S-26308 \| R 837 \| R-837 \| R837 \| Zyclara \| Aldara

Chemical Information

Molecular Formula	C14H16N4
CAS Registry Number	99011-02-6
SMILES	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Lip blister	23.03.01.016; 07.05.01.007	0.000658%		Not Available
General physical health deterioration	08.01.03.018	0.001317%		Not Available
Balance disorder	17.02.02.007; 08.01.03.081	0.000439%		Not Available
Application site hyperaesthesia	17.02.06.011; 12.07.01.023; 08.02.01.023	-	-	Not Available
Application site paraesthesia	17.02.06.012; 12.07.01.026; 08.02.01.026	-	-	Not Available
Dysstasia	15.03.05.011; 08.01.03.089; 17.02.02.012	-	-	Not Available
Lupus-like syndrome	15.06.02.004; 23.03.02.004; 10.04.03.003	0.001536%		Not Available
Acute coronary syndrome	24.04.04.011; 02.02.02.015	-	-	Not Available
Conjunctival hyperaemia	06.04.01.004	0.000878%		Not Available
Skin induration	23.03.03.020	0.001493%
Eye pruritus	06.04.05.006	0.001097%		Not Available
Application site discharge	23.03.03.049; 08.02.01.039; 12.07.01.039	-	-	Not Available
Respiratory tract congestion	22.02.07.003	-	-	Not Available
Lymphatic disorder	01.09.01.003	-	-	Not Available
Musculoskeletal stiffness	15.03.05.027	0.001185%		Not Available
Protein urine present	13.13.02.006	-	-	Not Available
Musculoskeletal discomfort	15.03.04.001	-	-	Not Available
Application site swelling	12.07.01.027; 08.02.01.027	0.001185%		Not Available
Skin burning sensation	23.03.03.021; 17.02.06.009	-	-	Not Available
Scrotal erythema	23.03.06.013; 21.12.02.008	-	-	Not Available
Eczema weeping	23.03.04.022	-	-	Not Available
Haemorrhage	24.07.01.002	0.001317%		Not Available
Pre-existing disease	08.01.03.059	-	-	Not Available
Cutaneous lupus erythematosus	15.06.02.007; 10.04.03.007; 23.03.02.008	0.001097%		Not Available
Rectal tenesmus	15.05.03.011; 07.03.03.001	-	-	Not Available
Cognitive disorder	19.21.02.001; 17.03.03.003	0.001097%
Skin oedema	23.06.04.001	-	-	Not Available
Application site discolouration	23.03.03.023; 12.07.01.030; 08.02.01.030	0.001185%		Not Available
Application site scar	23.03.11.010; 12.07.01.033; 08.02.01.033	0.000878%		Not Available
Congenital eye disorder	06.08.03.011; 03.01.01.002	-	-	Not Available

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