Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Red blood cell count decreased13.01.05.0070.000556%Not Available
Renal disorder20.01.02.0020.002040%Not Available
Renal failure20.01.03.0050.000726%Not Available
Respiratory arrest22.02.01.0090.000387%Not Available
Respiratory disorder22.02.07.0020.000436%Not Available
Respiratory distress22.02.01.0120.000581%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001307%
Rib fracture15.08.07.001; 12.04.07.0010.000742%Not Available
Right ventricular failure02.05.03.0020.000774%Not Available
Sarcoidosis10.02.06.0010.000097%Not Available
Scleroderma23.03.02.005; 15.06.01.002; 10.04.07.0010.000290%Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Shock24.06.02.002--Not Available
Sinus headache22.02.05.023; 17.14.01.0020.000371%
Sinusitis22.07.03.007; 11.01.13.005--
Skin cancer16.03.02.002; 23.08.02.0020.000371%Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin ulcer24.04.03.007; 23.07.03.0030.000927%
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.000097%
Somnolence17.02.04.006; 19.02.05.003--
Speech disorder22.02.05.034; 17.02.08.003; 19.19.02.0020.001113%Not Available
Sputum increased22.02.03.0070.000556%Not Available
Stomatitis07.05.06.005--
Stress19.06.02.0040.000742%Not Available
Sudden death08.04.01.003; 02.03.04.0130.000145%
Suffocation feeling22.02.08.0120.000556%Not Available
Supraventricular tachycardia02.03.03.012--
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