Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intestinal obstruction07.13.01.0020.000556%Not Available
Irritability19.04.02.013; 08.01.03.011--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.000742%Not Available
Joint swelling15.01.02.004--Not Available
Kidney infection20.01.09.004; 11.01.14.0060.000556%
Laboratory test abnormal13.18.01.001--Not Available
Laryngeal pain22.02.05.036--
Liver disorder09.01.08.001--Not Available
Local swelling08.01.03.0130.000742%Not Available
Localised infection11.01.08.0060.000290%Not Available
Loss of consciousness17.02.04.0040.002597%Not Available
Lower respiratory tract infection11.01.09.002; 22.07.01.0020.000556%Not Available
Lung disorder22.02.07.0010.002782%Not Available
Malaise08.01.01.003--
Memory impairment17.03.02.003; 19.20.01.003--
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth haemorrhage24.07.02.014; 07.05.02.0010.001298%
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasal congestion22.04.04.0010.001669%
Nasopharyngitis22.07.03.002; 11.01.13.0020.003524%Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nephrolithiasis20.04.01.002--
Nervous system disorder17.02.10.001--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema14.05.06.010; 08.01.07.0060.002226%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.006492%
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