Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Iloprost
Drug ID BADD_D01135
Description Iloprost is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
Indications and Usage Used for the treatment of pulmonary arterial hypertension.
Marketing Status Prescription; Discontinued
ATC Code B01AC11
DrugBank ID DB01088
KEGG ID D02721
MeSH ID D016285
PubChem ID 5311181
TTD Drug ID D05ZTH
NDC Product Code 54893-0017; 66215-302; 82231-109; 66215-303; 40016-013
Synonyms Iloprost | Ciloprost | ZK-36374 | ZK 36374 | ZK36374 | Ventavis
Chemical Information
Molecular Formula C22H32O4
CAS Registry Number 78919-13-8
SMILES CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood potassium increased13.11.01.0110.000371%Not Available
Blood pressure decreased13.14.03.0020.000927%Not Available
Blood pressure fluctuation24.06.01.0020.000556%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure systolic decreased13.14.03.0070.000371%Not Available
Bradycardia02.03.02.002--Not Available
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Breast pain21.05.05.0030.000371%
Bronchitis11.01.09.001; 22.07.01.0010.001298%
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.0010.001839%
Cardiac failure02.05.01.0010.002129%
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.001065%Not Available
Cardiomegaly02.04.02.0010.000097%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000194%Not Available
Cellulitis11.02.01.001; 23.09.01.0010.001113%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000290%Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.002411%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.006121%Not Available
Chills08.01.09.001; 15.05.03.0160.001298%
Choking22.02.05.0010.001113%Not Available
Cholelithiasis09.03.01.0020.001113%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000387%Not Available
Circulatory collapse24.06.02.0010.000532%Not Available
Coagulation time prolonged13.01.02.0060.000371%Not Available
Colitis07.08.01.001--
Coma17.02.09.001--Not Available
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