Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ifosfamide
Drug ID BADD_D01133
Description Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent.
Indications and Usage Used as a component of various chemotherapeutic regimens as third-line therapy for recurrent or refractory germ cell testicular cancer. Also used as a component of various chemotherapeutic regimens for the treatment of cervical cancer, as well as in conjunction with surgery and/or radiation therapy in the treatment of various soft tissue sarcomas. Other indications include treatment of osteosarcoma, bladder cancer, ovarian cancer. small cell lung cancer, and non-Hodgkin's lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01AA06
DrugBank ID DB01181
KEGG ID D00343
MeSH ID D007069
PubChem ID 3690
TTD Drug ID D02TLO
NDC Product Code 10019-925; 63323-142; 15308-0411; 10019-929; 57884-0006; 0338-3991; 0143-9530; 10019-926; 0143-9531; 10019-927; 65124-0001; 0703-3427; 0338-3993; 0703-3429
Synonyms Ifosfamide | Isofosfamide | Isophosphamide | Iphosphamide | Iso-Endoxan | Iso Endoxan | Holoxan | NSC-109,724 | NSC 109,724 | NSC109,724 | NSC-109724 | NSC 109724 | NSC109724 | Asta Z 4942
Chemical Information
Molecular Formula C7H15Cl2N2O2P
CAS Registry Number 3778-73-2
SMILES C1CN(P(=O)(OC1)NCCCl)CCCl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AminoaciduriaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
AnxietyAlpha-2A adrenergic receptorP08913T114487938249; 11425914
Arterial disorderElastinP15502Not Available2184650; 4077233; 10491730; 7033951; 3341387; 6489195; 2184657; 6394516; 6869203; 6616523; 9486085; 3277415; 11026649; 8562468; 6856486
Drug toleranceAlpha-2A adrenergic receptorP08913T114487938249; 11425914
GlycosuriaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
HypophosphataemiaBeta-2-microglobulinP61769T580802386379; 8774570; 9261752; 1503924; 8625085; 9950195; 2060086; 1718222; 8318805; 10234592; 8070011; 10817497; 2510931; 8018491; 7787938; 8570867; 12868118; 12402147; 7510155
Metabolic disorderS-adenosylmethionine decarboxylase proenzymeP17707T559226305362; 6121595; 6284819; 685624; 842265; 6617953; 204937
Metabolic disorderOrnithine decarboxylaseP11926T603666305362; 6121595; 6284819; 685624; 842265; 6617953; 204937
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bladder irritation20.02.02.020--Not Available
Blister12.01.06.002; 23.03.01.0010.000533%Not Available
Blood creatinine increased13.13.01.0040.000533%
Blood gonadotrophin increased13.10.03.008--Not Available
Blood oestrogen decreased13.10.05.010--Not Available
Blood pressure decreased13.14.03.002--Not Available
Body temperature increased13.15.01.0010.000533%Not Available
Bradycardia02.03.02.002--Not Available
Brain herniation17.11.01.002; 12.01.10.0010.000208%Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Bundle branch block left02.03.01.007--Not Available
Bundle branch block right02.03.01.011--Not Available
C-reactive protein increased13.09.01.0070.000533%Not Available
Capillary leak syndrome24.06.03.001; 08.01.07.012--
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiogenic shock02.05.01.003; 24.06.02.006--Not Available
Cardiomyopathy02.04.01.001--Not Available
Catatonia19.11.01.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000533%Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.001066%Not Available
Chills15.05.03.016; 08.01.09.0010.000533%
Cholestasis09.01.01.001--Not Available
Clumsiness17.01.02.0050.000533%Not Available
Coagulopathy01.01.02.001--Not Available
Colitis07.08.01.0010.000533%
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.0050.002398%
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
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