| Drug Name |
Ibuprofen lysine |
| Drug ID |
BADD_D01121 |
| Description |
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics.[A39074] The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.[A39075] Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID.[A39076]
On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer _in vivo_ by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.[A39194] |
| Indications and Usage |
Not Available |
| Marketing Status |
Prescription; OTC; Discontinued |
| ATC Code |
C01EB16; G02CC01; M01AE01; M02AA13; R02AX02 |
| DrugBank ID |
DB01050
|
| KEGG ID |
D06606
|
| MeSH ID |
D007052
|
| PubChem ID |
9841440
|
| TTD Drug ID |
D0R1QE
|
| NDC Product Code |
55292-122; 39822-1030; 66993-490; 46438-0003 |
| Synonyms |
Ibuprofen | alpha-Methyl-4-(2-methylpropyl)benzeneacetic Acid | Ibumetin | Ibuprofen, (+-)-Isomer | Ibuprofen, (R)-Isomer | Ibuprofen, (S)-Isomer | Ibuprofen, Aluminum Salt | Ibuprofen, Calcium Salt | Ibuprofen, Copper (2+) Salt | Ibuprofen, Magnesium Salt | Ibuprofen, Potassium Salt | Ibuprofen, Sodium Salt | Ibuprofen, Zinc Salt | Ibuprofen-Zinc | Ibuprofen Zinc | Motrin | Nuprin | Rufen | Salprofen | Trauma-Dolgit Gel | Trauma Dolgit Gel | Brufen |
