Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hyoscyamine sulfate
Drug ID BADD_D01115
Description Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine].[A228423] It is commonly extracted from plants in the _Solanaceae_ or nightshade family.[A228423] Research into the action of hyoscyamine in published literature dates back to 1826.[A228713] Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimuscarinic properties.[L31548,L31553] Although hyoscyamine is marketed in the United States, it is not FDA approved.[L31548,L31553]
Indications and Usage For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
Marketing Status Not Available
ATC Code A03BA03
DrugBank ID DB00424
KEGG ID D00719
MeSH ID D064692
PubChem ID 11479437
TTD Drug ID D0RG3O
NDC Product Code 53002-1135; 39328-048; 55742-013; 47781-011; 17856-0511; 51525-0113; 62068-318; 47781-014; 63187-411; 43199-011; 64543-111; 58657-427; 63629-1144; 43199-012; 43063-321; 68220-113; 71335-1159; 51525-0115; 43199-013; 70156-104; 68071-5024; 17856-0514; 64543-118; 68220-118; 63629-1030; 0225-0295; 42192-338; 47781-012; 0485-0082; 63629-1028; 61919-297; 54288-111; 64543-112; 70934-937; 63187-058; 42192-340; 54838-506; 70156-105; 68220-112; 68220-115; 47781-013; 68047-252; 39328-047; 51525-0112; 71335-1647; 0037-9001; 68047-253; 63629-1031; 71335-0788; 42192-339; 70518-3027; 54838-511; 70156-106
Synonyms Hyoscyamine | Atropine, 3(S)-endo-Isomer | Cytospaz | Hyoscyamine Sulfate Anhydrous | Hyoscyamine Hydrochloride | Hyoscyamine Sulfate | Atropine Sulfate, 3(S)-endo-Isomer | Anaspaz | Hyoscyamine Hydrobromide
Chemical Information
Molecular Formula C34H48N2O10S
CAS Registry Number 620-61-1
SMILES CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.OS(= O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Drug diversion26.06.01.003--Not Available
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