Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydroxyurea
Drug ID BADD_D01110
Description An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indications and Usage For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Marketing Status Prescription; Discontinued
ATC Code L01XX05
DrugBank ID DB01005
KEGG ID D00341
MeSH ID D006918
PubChem ID 3657
TTD Drug ID D07CWD
NDC Product Code 70518-0916; 0904-6939; 51927-0072; 49452-3650; 0003-6337; 60429-265; 55154-7143; 0003-0830; 10135-702; 71770-120; 49884-724; 55512-0003; 68084-284; 51552-0851; 17337-0022; 0003-6336; 35369-0006; 0555-0882; 0003-6335; 42291-321; 51927-2655; 71052-323; 69315-164; 17337-0023; 71770-105
Synonyms Hydroxyurea | Hydroxycarbamid | Oncocarbide | Hydrea
Chemical Information
Molecular Formula CH4N2O2
CAS Registry Number 127-07-1
SMILES C(=O)(N)NO
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Chronic myeloid leukaemiaTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
HepatomegalyTyrosine-protein kinase ABL1P00519T6350511841409; 11273186; 9516377; 15510207
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperglycaemia05.06.02.002; 14.06.02.0020.000533%
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkalaemia14.05.03.0010.001865%
Hyperkeratosis23.01.01.0010.000533%
Hypersensitivity10.01.03.003--
Hypersensitivity vasculitis10.02.02.017; 01.01.04.008; 24.05.02.012; 23.06.02.0050.000533%Not Available
Hypersplenism01.09.02.002--Not Available
Hypertension24.08.02.001--
Hyperuricaemia14.09.01.0030.001332%
Hypoaesthesia17.02.06.0230.001332%Not Available
Hypocalcaemia14.04.01.0040.000533%
Hypoglycaemia14.06.03.001; 05.06.03.0010.000799%
Hypomagnesaemia14.04.02.001--
Hyponatraemia14.05.04.0020.000799%
Hypotension24.06.03.002--
Hypoxia22.02.02.0030.000533%
Infection11.01.08.0020.000556%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Inguinal hernia07.16.02.0010.000799%Not Available
Interstitial lung disease22.01.02.003; 10.02.01.0330.008792%Not Available
Intestinal obstruction07.13.01.0020.000139%Not Available
Laboratory test abnormal13.18.01.001--Not Available
Laceration23.03.11.004; 12.01.06.0060.000208%Not Available
Leukaemia16.01.03.001; 01.10.03.0010.000278%
Leukocytosis01.02.01.0020.003996%
Leukopenia01.02.02.001--Not Available
Liver disorder09.01.08.0010.001598%Not Available
Loss of consciousness17.02.04.004--Not Available
Lung disorder22.02.07.0010.000533%Not Available
Lung infiltration22.01.02.0040.000208%Not Available
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