| Pharmaceutical Information |
| Drug Name |
Hydrocodone bitartrate |
| Drug ID |
BADD_D01085 |
| Description |
Hydrocodone is a synthetic opioid derivative of codeine.[T116] It is commonly used in combination with [acetaminophen] to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by [dextromethorphan] in current cough and cold formulations. Hydrocodone's more potent metabolite, [hydromorphone] has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.[L9025] |
| Indications and Usage |
For relief of moderate to moderately severe pain. Also used for the symptomatic relief of nonproductive cough, alone or in combination with other antitussives or expectorants. |
| Marketing Status |
Discontinued; Prescription |
| ATC Code |
R05DA03 |
| DrugBank ID |
DB00956
|
| KEGG ID |
D03725
|
| MeSH ID |
D006853
|
| PubChem ID |
20831824
|
| TTD Drug ID |
D0X5KF
|
| NDC Product Code |
47781-412; 51634-0014; 63275-4100; 59011-273; 47781-413; 59011-271; 47781-396; 0406-1582; 47781-411; 82393-123; 61960-9193; 59011-277; 59116-4751; 67509-007; 61919-494; 47781-392; 59011-274; 0406-1559; 47781-409; 59011-275; 0792-0543; 61919-118; 38779-0764; 47781-394; 49812-0132; 51552-0677; 59116-4750; 47781-395; 47781-410; 49452-0033; 59011-272; 47781-398; 59011-276; 47781-414; 47781-393; 47781-397; 62991-3091 |
| Synonyms |
Hydrocodone | Hydrocodon | Dihydrocodeinone | Dicodid | Robidone | Hydrocodone Bitartrate | Hydrocodone Tartrate (1:1), Hydrate (2:5) | Hydrocodeinonebitartrate | Hydrocon | Codinovo | Hycodan | Hycon |
|
| Chemical Information |
| Molecular Formula |
C22H27NO9 |
| CAS Registry Number |
143-71-5 |
| SMILES |
CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4.C(C(C(=O)O)O)(C(=O)O)O |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
|
| Dizziness | 24.06.02.007; 17.02.05.003; 02.01.02.004 | - | - | |
|
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