Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Hydrochlorothiazide
Drug ID BADD_D01083
Description Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Indications and Usage For the treatment of high blood pressure and management of edema.
Marketing Status Prescription; Discontinued
ATC Code C03AA03
DrugBank ID DB00999
KEGG ID D00340
MeSH ID D006852
PubChem ID 3639
TTD Drug ID D0U4UQ
NDC Product Code 68788-7683; 69584-362; 68788-7648; 61919-580; 50090-0724; 0591-0347; 63187-440; 12828-0008; 71205-090; 62332-070; 65862-113; 70934-789; 68788-8126; 71335-0269; 68788-6844; 71610-471; 61919-293; 55700-843; 50090-2706; 70934-916; 67544-739; 60429-888; 62512-0028; 71610-261; 29300-130; 76282-155; 0172-2089; 50228-112; 70518-2666; 71610-488; 50228-111; 70518-1595; 63629-1220; 63187-553; 50090-5333; 60429-889; 71335-1716; 71335-1481; 35356-807; 70934-170; 70518-2629; 0615-8149; 60760-499; 11722-060; 43063-747; 63187-441; 71335-1350; 68071-4758; 71205-161; 68071-4933; 53002-4972; 50090-3186; 71335-0770; 50090-2727; 67046-378; 68071-2159; 42291-315; 0228-2820; 68071-2405; 43353-719; 63187-548; 51655-506; 43353-717; 71610-014; 53002-4970; 68071-2654; 68071-4176; 0378-0810; 70518-0210; 43063-933; 57451-1127; 63629-1219; 71610-276; 60760-199; 61919-695; 42419-001; 51927-0172; 71335-0145; 42708-028; 60429-890; 68788-8928; 42708-027; 59746-382; 46708-868; 0172-2083; 70518-3002; 68071-5266; 68071-4819; 68071-2456; 68071-4963; 71335-1451; 50090-2744; 68071-5273; 60687-593; 71335-1976; 42708-086; 55154-1483; 50090-0140; 43353-240; 65862-133; 55700-758; 50090-0141; 72789-176; 63629-8498; 71610-323; 63629-7782; 68788-7475; 16729-183; 68071-2462; 68788-7400; 65862-134; 71205-589; 55289-565; 68788-7790; 71610-015; 72189-263; 69367-122; 71610-139; 71335-1713; 70518-1486; 70518-2550; 68071-4361; 63629-1218; 67296-1682; 68071-3323; 23155-009; 16729-182; 68071-5211; 53002-1702; 63629-8991; 71205-980; 51407-331; 60760-430; 50228-146; 0527-1413; 69315-155; 68645-510; 69367-219; 67296-1423; 63187-367; 16729-184; 68788-9965; 0527-1414; 51655-272; 50090-5672; 71610-500; 51407-332; 55700-301; 43547-397; 57237-002; 53808-1111; 70518-1728; 29300-129; 66267-106; 63629-1121; 23155-008; 42708-079; 50090-2171; 67296-1174; 49452-3575; 43063-755; 70518-2540; 69315-130; 0615-7974; 71335-0067; 69315-131; 51407-330; 76282-154; 67296-1508; 68071-1736; 0615-8344; 29300-128; 65862-323; 71335-0652; 69584-361; 29930-200; 63187-074; 58118-0123; 55154-5686; 68071-2411; 70934-930; 68071-4438; 55700-006; 69367-123; 60760-315; 70934-074; 50090-1088; 57451-1143; 70934-345; 55488-0300; 67296-1274; 51927-1611; 50090-5057; 68071-4807; 43547-398; 46708-438; 71205-419; 63629-8992; 68071-2607; 70518-0335
Synonyms Hydrochlorothiazide | HCTZ | Dichlothiazide | Dihydrochlorothiazide | HydroDIURIL | Oretic | Sectrazide | Esidrix | Esidrex | Hypothiazide
Chemical Information
Molecular Formula C7H8ClN3O4S2
CAS Registry Number 58-93-5
SMILES C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Urinary abnormalitiesProstaglandin E2 receptor EP1 subtypeQ9BGL8Not Available2156653; 9089805; 1340758; 10972691; 6580903; 2076411; 1325325; 6281301; 3586136; 6894567; 3422697; 3885156; 3855398; 6547151; 9989691; 2348646; 7018797
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bundle branch block left02.03.01.0070.000067%Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
C-reactive protein increased13.09.01.0070.000067%Not Available
Cardiac arrest02.03.04.0010.000333%
Cardiac failure02.05.01.001--
Cellulitis23.09.01.001; 11.02.01.0010.000044%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.000222%Not Available
Chills15.05.03.016; 08.01.09.0010.000089%
Completed suicide19.12.01.001; 08.04.01.0100.000046%Not Available
Confusional state19.13.01.001; 17.02.03.0050.000822%
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.0010.000244%
Cutaneous vasculitis24.05.02.004; 23.06.02.001; 10.02.02.003--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.000044%
Deafness04.02.01.0010.000444%Not Available
Deafness neurosensory17.04.07.001; 04.02.01.0020.000089%Not Available
Death08.04.01.001--
Dehydration14.05.05.0010.000511%
Delirium19.13.02.0010.000111%
Depressed mood19.15.02.0010.000067%Not Available
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.0020.000111%
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diabetic ketoacidosis05.07.03.001; 14.07.03.0010.000067%Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
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