| Pharmaceutical Information |
| Drug Name |
Hydrochlorothiazide |
| Drug ID |
BADD_D01083 |
| Description |
Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459]
Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444] |
| Indications and Usage |
Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450] |
| Marketing Status |
approved; vet_approved |
| ATC Code |
C03AA03 |
| DrugBank ID |
DB00999
|
| KEGG ID |
D00340
|
| MeSH ID |
D006852
|
| PubChem ID |
3639
|
| TTD Drug ID |
D0U4UQ
|
| NDC Product Code |
65862-113; 42708-079; 0172-2089; 50090-1088; 50090-6158; 51655-272; 53002-4970; 57237-002; 62135-448; 63629-1219; 65862-133; 68071-3443; 68071-4963; 68071-5211; 69315-155; 70518-0335; 70518-2540; 70934-916; 71335-1451; 72789-176; 72789-296; 0591-0347; 55488-0300; 42708-028; 50090-6157; 51407-332; 58118-0123; 60687-593; 60687-683; 60760-499; 62135-449; 63187-441; 63629-7782; 63629-8992; 68071-3238; 68071-5284; 68788-8378; 68788-8928; 70934-789; 70934-930; 71205-090; 71205-161; 71610-015; 71610-276; 71610-697; 76282-155; 65862-323; 42708-086; 42708-164; 50090-0724; 53002-4972; 61919-293; 62332-070; 0527-1413; 70518-2629; 71205-793; 71335-0145; 71335-0652; 71335-1481; 71335-9647; 61919-580; 61919-695; 63629-1220; 67296-1487; 67296-1508; 68645-510; 68788-8417; 69584-362; 70518-1676; 71610-261; 72189-263; 57451-1127; 16729-182; 29300-128; 29300-129; 43353-240; 43353-719; 43547-398; 50090-5672; 50090-6156; 51655-088; 51655-502; 51655-616; 0228-2820; 63629-1218; 63629-8991; 68788-6844; 68788-8126; 69584-361; 70518-1728; 70518-2550; 70518-2666; 70934-170; 71335-0770; 0615-8449; 72789-303; 11722-060; 42419-001; 65862-134; 43063-747; 50268-404; 51655-522; 55700-006; 60760-430; 63187-440; 68071-2654; 68071-5266; 69315-130; 70518-3633; 70518-3749; 71205-589; 71205-980; 71335-0269; 12658-0405; 49452-3575; 23155-009; 35356-807; 43063-755; 50090-2744; 50090-6372; 63187-074; 63629-1121; 67296-2043; 67544-739; 68071-5273; 68788-7683; 70518-1595; 71335-1350; 71610-139; 71610-500; 0615-8450; 51927-0172; 51927-1611; 57451-1143; 16729-184; 23155-008; 23155-764; 43547-397; 50090-2727; 50090-5333; 50090-6532; 50228-111; 59746-382; 60760-199; 67296-1274; 68071-2159; 68788-7790; 69315-131; 69367-219; 0527-1414; 70518-0597; 70934-883; 71205-419; 71205-751; 71335-1713; 71610-014; 71610-471; 0615-8149; 12658-0605; 29300-130; 42708-027; 43353-717; 0172-2083; 50090-2706; 51655-674; 53002-1702; 53808-1111; 60760-315; 63187-367; 63187-548; 63629-8498; 68071-2607; 70934-074; 0615-7974; 12828-0008; 62512-0028; 43063-933; 50228-146; 51407-330; 51655-422; 51655-515; 51655-831; 63187-553; 67296-1174; 70518-0210; 70518-1486; 71335-0067; 71335-1976; 71610-488; 76282-154; 12658-0538; 16729-183; 46708-438; 50090-2171; 50228-112; 51407-331 |
| UNII |
0J48LPH2TH
|
| Synonyms |
Hydrochlorothiazide | HCTZ | Dichlothiazide | Dihydrochlorothiazide | HydroDIURIL | Oretic | Sectrazide | Esidrix | Esidrex | Hypothiazide |
|
| Chemical Information |
| Molecular Formula |
C7H8ClN3O4S2 |
| CAS Registry Number |
58-93-5 |
| SMILES |
C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
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