Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Hydrochlorothiazide
Drug ID BADD_D01083
Description Hydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.[A185138] Many combination products are available containing hydrochlorothiazide and angiotensin converting enzyme inhibitors[L8390,L8423] or angiotensin II receptor blockers.[L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444]
Indications and Usage Hydrochlorothiazide is indicated alone or in combination for the management of edema associated with congestive heart failure, hepatic cirrhosis, nephrotic syndrome, acute glomerulonephritis, chronic renal failure, and corticosteroid and estrogen therapy.[L8447,L8450] Hydrochlorothiazide is also indicated alone or in combination for the management of hypertension.[A185138,L8447,L8450]
Marketing Status approved; vet_approved
ATC Code C03AA03
DrugBank ID DB00999
KEGG ID D00340
MeSH ID D006852
PubChem ID 3639
TTD Drug ID D0U4UQ
NDC Product Code 65862-113; 42708-079; 0172-2089; 50090-1088; 50090-6158; 51655-272; 53002-4970; 57237-002; 62135-448; 63629-1219; 65862-133; 68071-3443; 68071-4963; 68071-5211; 69315-155; 70518-0335; 70518-2540; 70934-916; 71335-1451; 72789-176; 72789-296; 0591-0347; 55488-0300; 42708-028; 50090-6157; 51407-332; 58118-0123; 60687-593; 60687-683; 60760-499; 62135-449; 63187-441; 63629-7782; 63629-8992; 68071-3238; 68071-5284; 68788-8378; 68788-8928; 70934-789; 70934-930; 71205-090; 71205-161; 71610-015; 71610-276; 71610-697; 76282-155; 65862-323; 42708-086; 42708-164; 50090-0724; 53002-4972; 61919-293; 62332-070; 0527-1413; 70518-2629; 71205-793; 71335-0145; 71335-0652; 71335-1481; 71335-9647; 61919-580; 61919-695; 63629-1220; 67296-1487; 67296-1508; 68645-510; 68788-8417; 69584-362; 70518-1676; 71610-261; 72189-263; 57451-1127; 16729-182; 29300-128; 29300-129; 43353-240; 43353-719; 43547-398; 50090-5672; 50090-6156; 51655-088; 51655-502; 51655-616; 0228-2820; 63629-1218; 63629-8991; 68788-6844; 68788-8126; 69584-361; 70518-1728; 70518-2550; 70518-2666; 70934-170; 71335-0770; 0615-8449; 72789-303; 11722-060; 42419-001; 65862-134; 43063-747; 50268-404; 51655-522; 55700-006; 60760-430; 63187-440; 68071-2654; 68071-5266; 69315-130; 70518-3633; 70518-3749; 71205-589; 71205-980; 71335-0269; 12658-0405; 49452-3575; 23155-009; 35356-807; 43063-755; 50090-2744; 50090-6372; 63187-074; 63629-1121; 67296-2043; 67544-739; 68071-5273; 68788-7683; 70518-1595; 71335-1350; 71610-139; 71610-500; 0615-8450; 51927-0172; 51927-1611; 57451-1143; 16729-184; 23155-008; 23155-764; 43547-397; 50090-2727; 50090-5333; 50090-6532; 50228-111; 59746-382; 60760-199; 67296-1274; 68071-2159; 68788-7790; 69315-131; 69367-219; 0527-1414; 70518-0597; 70934-883; 71205-419; 71205-751; 71335-1713; 71610-014; 71610-471; 0615-8149; 12658-0605; 29300-130; 42708-027; 43353-717; 0172-2083; 50090-2706; 51655-674; 53002-1702; 53808-1111; 60760-315; 63187-367; 63187-548; 63629-8498; 68071-2607; 70934-074; 0615-7974; 12828-0008; 62512-0028; 43063-933; 50228-146; 51407-330; 51655-422; 51655-515; 51655-831; 63187-553; 67296-1174; 70518-0210; 70518-1486; 71335-0067; 71335-1976; 71610-488; 76282-154; 12658-0538; 16729-183; 46708-438; 50090-2171; 50228-112; 51407-331
UNII 0J48LPH2TH
Synonyms Hydrochlorothiazide | HCTZ | Dichlothiazide | Dihydrochlorothiazide | HydroDIURIL | Oretic | Sectrazide | Esidrix | Esidrex | Hypothiazide
Chemical Information
Molecular Formula C7H8ClN3O4S2
CAS Registry Number 58-93-5
SMILES C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Milk-alkali syndrome14.01.02.0050.000020%Not Available
Post-traumatic stress disorder19.06.06.0020.000010%Not Available
Thrombocytopenia neonatal01.08.01.010; 18.04.03.005--Not Available
Ventricular asystole02.03.04.0180.000025%Not Available
Intestinal villi atrophy07.11.03.0100.000010%Not Available
Subacute cutaneous lupus erythematosus23.03.02.020; 15.06.02.012; 10.04.03.0120.000030%Not Available
Nephrogenic anaemia20.01.01.007; 01.03.04.0010.000010%Not Available
Hyponatraemic encephalopathy17.13.01.011; 14.05.04.0070.000025%Not Available
Stress cardiomyopathy24.04.04.026; 02.04.01.0120.000040%Not Available
Skin plaque23.03.03.0440.000030%Not Available
Psychological trauma19.01.02.0170.000010%Not Available
Fulminant type 1 diabetes mellitus05.06.01.013; 14.06.01.013; 10.04.08.0130.000015%Not Available
Hyponatraemic seizure17.12.03.025; 14.05.04.008--Not Available
Hypoosmolar state14.05.01.0100.000010%Not Available
Gluten sensitivity14.02.01.008; 10.01.01.031; 07.17.01.0090.000034%Not Available
End stage renal disease20.01.03.0190.000010%Not Available
Bell's palsy17.04.03.011--Not Available
Cutaneous T-cell lymphoma23.07.04.029; 16.17.03.002; 01.11.03.0020.000147%Not Available
Cutaneous T-cell lymphoma stage II23.07.04.033; 16.17.03.006; 01.11.03.0060.000015%Not Available
Cutaneous T-cell lymphoma stage III23.07.04.034; 16.17.03.007; 01.11.03.0070.000010%Not Available
Gait inability17.02.05.069; 08.01.02.0110.000022%Not Available
Hepatic cytolysis09.01.07.0360.000010%Not Available
Illness08.01.03.0910.000037%Not Available
Lymph node calcification01.09.01.0320.000010%Not Available
Muscle discomfort15.05.03.0370.000010%Not Available
Pancreatogenous diabetes05.06.01.018; 14.06.01.018; 07.18.02.0150.000010%Not Available
Pharyngeal swelling22.04.05.0280.000010%Not Available
Sprue-like enteropathy07.17.01.014; 14.02.01.0110.000035%Not Available
Taste disorder17.02.07.029; 07.14.03.0040.000022%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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