Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gemifloxacin
Drug ID BADD_D01013
Description Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase and topoisomerase IV, which are essential for bacterial growth.
Indications and Usage For the treatment of bacterial infection caused by susceptible strains such as S. pneumoniae, H. influenzae, H. parainfluenzae, or M. catarrhalis, S. pneumoniae (including multi-drug resistant strains [MDRSP]), M. pneumoniae, C. pneumoniae, or K. pneumoniae.
Marketing Status Prescription
ATC Code J01MA15
DrugBank ID DB01155
KEGG ID D08012
MeSH ID D000077735
PubChem ID 5464436
TTD Drug ID D0VR7W
NDC Product Code Not Available
Synonyms Gemifloxacin | 7-(3-aminomethyl-4-methoxyimino-pyrrolidine-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)-naphthyridine-3-carboxylic acid | Factive | Gemifloxacin Mesylate | SB-265805 | SB265805 | SB 265805 | LB 20304 | LB-20304 | LB20304
Chemical Information
Molecular Formula C18H20FN5O4
CAS Registry Number 210353-54-1
SMILES CON=C1CN(CC1CN)C2=C(C=C3C(=O)C(=CN(C3=N2)C4CC4)C(=O)O)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Headache17.14.01.001--
Hepatitis cholestatic09.01.01.002--Not Available
Hyperbilirubinaemia09.01.01.003; 01.06.04.003; 14.11.01.010--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyponatraemia14.05.04.002--
Hypovolaemia14.05.05.002--Not Available
Immune system disorder10.02.01.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice hepatocellular09.01.01.006--Not Available
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Megacolon07.02.05.002--Not Available
Menopausal symptoms21.02.02.002--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myasthenia gravis17.05.04.001; 15.05.08.001; 10.04.05.001--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutrophil count decreased13.01.06.010--
Neutrophil count increased13.01.06.011--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Oral mucosal blistering07.05.05.017--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
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