Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gemeprost
Drug ID BADD_D01011
Description Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion. It is available as vaginal suppositories and also used in combination with the antiprogestin and mifepristone for termination of 1st- and 2nd-trimester pregnancy [A19726]. It is not FDA-approved but available in Japan marketed as Preglandin.
Indications and Usage Indicated for the softening and dilatation of the cervix uteri prior to transcervical, intrauterine operative procedures in the first trimester of pregnancy or facilitating therapeutic termination of pregnancy in patients in the second trimester of gestation.
Marketing Status Not Available
ATC Code G02AD03
DrugBank ID DB08964
KEGG ID D02073
MeSH ID C021182
PubChem ID 5282237
TTD Drug ID D0EC5X
NDC Product Code Not Available
Synonyms gemeprost | 16,16-dimethyl-delta(2)-PGE1 methyl ester | Preglandin | 16,16-DMTDPGEME | 16,16-dimethyl-delta(2)-prostaglandin E1 methyl ester | Cervagem | Cervagème | gemeprost, (2E,11alpha,13E,15R)-isomer | PG802 | Cergem | 16,16-dimethyl-trans-delta(2)-PGE(1) methyl ester | 16,16-dimethyl-trans-delta(2)-prostaglandin E(1) methyl ester | ONO 802 | ONO-802
Chemical Information
Molecular Formula C23H38O5
CAS Registry Number 64318-79-2
SMILES CCCCC(C)(C)C(C=CC1C(CC(=O)C1CCCCC=CC(=O)OC)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain lower07.01.05.010--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Arteriospasm coronary24.04.04.005; 02.02.02.005--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dysmenorrhoea21.01.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Headache17.14.01.001--
Hypotension24.06.03.002--
Muscular weakness17.05.03.005; 15.05.06.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Palpitations02.01.02.003--
Surgery25.01.02.003--Not Available
Tachycardia02.03.02.007--Not Available
Uterine pain21.07.01.008--
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Vomiting07.01.07.003--
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
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