Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadoteridol
Drug ID BADD_D00993
Description Gadoteridol provides contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. Gadoteridol can also be used for whole body contrast enhanced MRI including the head, neck, liver, breast, musculoskeletal system and soft tissue pathologies. n MRI, visualization of normal and pathological brain tissue depends in part on variations in the radiofrequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in T2. When placed in a magnetic field, gadoteridol shortens the T1 relaxation time in tissues where it accumulates. Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadoteridol in lesions such as neoplasms, abscesses, and subacute infarcts.
Indications and Usage Gadoteridol is an MRI contrast agent used for contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. Gadoteridol can also be used for whole body contrast enhanced MRI including the head, neck, liver, breast, musculoskeletal system and soft tissue pathologies.
Marketing Status Prescription
ATC Code V08CA04
DrugBank ID DB00597
KEGG ID D01137
MeSH ID C062402
PubChem ID 60714
TTD Drug ID D0M1PL
NDC Product Code 0270-1111; 57876-111; 73435-009
Synonyms gadoteridol | Gd-HP-DO3A | gadolinium 1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane | GdHPDO3A | Gd-hydroxypropyl-D03A | gadolinium 1,4,7-tris(carboxymethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane | gadolinium HP-DO3A | Gd-HPDO3A | Gd(DO3A) | Gd-HP-D03A | Prohance | SQ 32692 | SQ 32,692 | SQ-32692
Chemical Information
Molecular Formula C17H29GdN4O7
CAS Registry Number 120066-54-8
SMILES CC(CN1CCN(CCN(CCN(CC1)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-])O.[Gd+3]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac arrest02.03.04.001--
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Coordination abnormal17.02.02.004--Not Available
Cough22.02.03.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Deafness transitory17.04.07.003; 04.02.01.004--Not Available
Death08.04.01.001--
Depressed level of consciousness17.02.04.002--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysgeusia07.14.03.001; 17.02.07.003--
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Feeling abnormal08.01.09.014--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
The 1th Page    1 2 3    Next   Last    Total 3 Pages