Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gadobenate dimeglumine
Drug ID BADD_D00983
Description Gadobenic acid (in the form of gadobenate dimeglumine) is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for visualizing the CNS and heart. In contrast to conventional extracellular fluid contrast agents, gadobenate dimeglumine is characterized by a weak and transient binding capacity to serum proteins. This binding leads to an increased relaxivity of gadobenate dimeglumine and, consequently, to a considerably increased signal intensity over that of other agents.
Indications and Usage Gadobenate Dimeglumine is an MRI contrast agent used primarily for MR imaging of the liver. It can also be used for MRI of the heart, as well as and central nervous system in adults to visualize lesions with abnormal brain vascularity or abnormalities in the blood brain barrier, the brain, spine, or other associated tissues.
Marketing Status Prescription
ATC Code V08CA08
DrugBank ID DB00743
KEGG ID D04283
MeSH ID C064572
PubChem ID 105125
TTD Drug ID D01OIL
NDC Product Code 0270-5264; 57876-333; 0270-5164
Synonyms gadobenic acid | 3,6,9-triaza-12-oxa-3,6,9-tricarboxymethylene-10-carboxy-13-phenyltridecanoic acid, gadolinium | Gd-BOPTA | gadobenic acid, dimeglumine salt | gadobenate dimeglumine | gadolinium-BOPTA-Dimeg | MultiHance | Gd(BOPTA)2 | B 19036 | B-19036 | gadolinium-benzyloxypropionyl tetraacetate
Chemical Information
Molecular Formula C22H31N3O11
CAS Registry Number 113786-33-7
SMILES C1=CC=C(C=C1)COCC(C(=O)O)N(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Defaecation urgency07.02.04.001--Not Available
Depressed level of consciousness17.02.04.002--
Dermatitis23.03.04.002--Not Available
Dermatitis atopic10.01.04.004; 23.03.04.016--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Ear disorder04.03.01.001--Not Available
Ear pain04.03.01.003--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.001--Not Available
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram QT shortened13.14.05.030--Not Available
Electrocardiogram T wave inversion13.14.05.007--Not Available
Enteritis07.08.03.002--
Eosinophil count increased13.01.06.004--Not Available
Erythema23.03.06.001--Not Available
Extrasystoles02.03.02.003--Not Available
Extravasation08.01.03.008--Not Available
Eye disorder06.08.03.001--Not Available
Eye pain06.08.03.002--
Eyelid oedema10.01.05.001; 06.04.04.004; 23.04.01.003--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fat embolism24.01.01.012; 12.01.08.003--Not Available
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