Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gabapentin
Drug ID BADD_D00981
Description Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Indications and Usage For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX12
DrugBank ID DB00996
KEGG ID D00332
MeSH ID D000077206
PubChem ID 3446
TTD Drug ID D0J0ZS
NDC Product Code 60760-066; 70010-118; 42582-116; 71093-162; 60760-517; 70518-2912; 60760-741; 63187-909; 69434-043; 71335-1018; 80425-0128; 69097-812; 51224-119; 55154-6846; 80425-0097; 70166-751; 50436-0428; 50436-0383; 61919-417; 68071-4784; 71610-631; 69097-811; 17856-0600; 64380-868; 76282-706; 43602-470; 76420-014; 59762-4355; 80425-0079; 0228-2637; 71610-146; 69097-814; 67877-224; 53002-3423; 0904-6586; 68071-2458; 68071-3086; 42582-115; 55154-3363; 68788-9509; 60687-580; 61919-350; 63187-785; 17351-5010; 63275-9970; 31722-167; 68071-4978; 50090-5045; 80425-0150; 71205-619; 71093-122; 63629-8488; 0904-6823; 63629-3063; 68071-4113; 52427-803; 71610-421; 16714-662; 52427-806; 71205-931; 65162-102; 55700-780; 70518-1469; 68071-4049; 63187-148; 69097-813; 71335-1348; 68071-3230; 53002-4423; 45865-405; 71610-432; 69434-044; 68788-7839; 70934-123; 57884-2002; 65841-706; 71335-2005; 65015-740; 71093-161; 65862-198; 50436-4290; 55154-7992; 43602-471; 71093-163; 50090-3912; 68788-7941; 69097-943; 62207-924; 68788-7098; 58657-720; 0615-8340; 69844-056; 70010-927; 45963-556; 62207-926; 63739-236; 71335-2004; 71335-0073; 43547-384; 43353-081; 50090-0896; 68788-7135; 0071-0805; 55370-004; 67296-1709; 59088-725; 70010-109; 71335-1997; 0071-0803; 55154-8194; 71335-1200; 43063-664; 70934-339; 71335-1041; 57884-2001; 43063-673; 72189-113; 42582-114; 62756-138; 62207-928; 62756-137; 50090-5125; 50090-4445; 71335-1454; 63187-010; 71335-1198; 68001-412; 50228-177; 71335-1026; 70010-926; 60760-067; 62756-204; 68788-7757; 55700-950; 59762-5050; 0615-8342; 71335-1313; 50090-5322; 55154-7989; 50228-178; 71205-457; 51407-048; 68788-7848; 63739-591; 16714-663; 71335-1490; 50228-181; 67296-1710; 50090-4893; 69367-132; 0395-8055; 76282-627; 42765-018; 62207-923; 53002-6423; 71335-0254; 68788-7104; 57884-0010; 43547-389; 60687-507; 55700-584; 72189-178; 0228-2636; 58657-722; 62756-202; 71335-0351; 60687-591; 55700-544; 55154-3366; 65162-698; 63187-983; 80425-0034; 69367-344; 65862-199; 70120-123; 43353-075; 67877-223; 50268-352; 60760-605; 67877-429; 71335-1093; 71610-442; 71335-0820; 71335-1601; 71610-400; 80425-0149; 63187-988; 72189-109; 71610-125; 61919-660; 70518-0810; 76420-047; 46144-104; 31722-150; 72789-123; 71205-160; 63187-392; 68788-7444; 69844-055; 65862-385; 59762-5025; 80425-0163; 70518-1288; 10135-647; 71610-135; 55154-6845; 68788-7847; 71335-1496; 70518-2776; 67296-1721; 70518-2614; 65862-523; 53746-102; 43547-385; 80425-0036; 63187-149; 42806-511; 42192-608; 65862-524; 68788-7869; 71610-059; 71610-426; 62207-927; 71205-532; 60592-300; 80425-0031; 51224-219; 68071-1292; 55700-815; 71610-410; 68788-7614; 65977-0054; 71335-1287; 71205-317; 71610-090; 63629-8060; 71205-929; 65841-705; 70010-928; 71093-112; 60687-602; 59762-4135; 68554-0128; 59762-4460; 68071-2600; 45865-356; 71335-1497; 70518-3330; 70518-2098; 70934-933; 71335-0993; 70518-0483; 63739-903; 80425-0035; 68382-205; 61919-640; 64380-867; 63739-904; 50228-180; 72189-092; 69367-135; 69097-815; 69367-347; 71610-195; 70518-1160; 72789-055; 59762-4030; 76282-707; 70518-2493; 71610-185; 16714-503; 80425-0033; 63187-248; 16714-661; 72789-127; 71205-932; 63629-7309; 60760-088; 63629-8492; 62756-139; 63629-8489; 31722-149; 63187-031; 43602-469; 52048-1980; 0071-0513; 76282-323; 68788-7431; 45963-555; 49483-607; 70934-593; 25000-105; 68382-204; 35356-708; 55700-949; 70934-651; 53002-5472; 68071-2308; 59762-4240; 71335-1453
Synonyms Gabapentin | 1-(Aminomethyl)cyclohexaneacetic Acid | Neurontin | Gabapentin Hexal | Convalis | Gabapentin-Ratiopharm | Gabapentin Ratiopharm | Novo-Gabapentin | Novo Gabapentin | NovoGabapentin | PMS-Gabapentin | Apo-Gabapentin | Apo Gabapentin | ApoGabapentin | Gabapentin Stada
Chemical Information
Molecular Formula C9H17NO2
CAS Registry Number 60142-96-3
SMILES C1CCC(CC1)(CC(=O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AkathisiaD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
Anxiety5-hydroxytryptamine receptor 3AP46098T6459111715630; 15738862; 15959450; 15627046
Anxiety5-hydroxytryptamine receptor 2AP28223T3206011715630; 15738862; 15959450; 15627046
AnxietyHistamine H1 receptorP35367T7791311715630; 15738862; 15959450; 15627046
AnxietyMuscarinic acetylcholine receptor M1P11229T2889311715630; 15738862; 15959450; 15627046
AnxietyAlpha-1A adrenergic receptorP35348T9260911715630; 15738862; 15959450; 15627046
Anxiety5-hydroxytryptamine receptor 2BP41595T3120411715630; 15738862; 15959450; 15627046
Diabetic complications NECGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Q06210Not Available11163803; 12802498; 10997922
Diabetic complications NECTransforming growth factor beta-1 proproteinP01137T9725711163803; 12802498; 10997922
Diabetic complications renalGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Q06210Not Available11163803; 12802498; 10997922
Diabetic complications renalTransforming growth factor beta-1 proproteinP01137T9725711163803; 12802498; 10997922
DystoniaD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
NauseaMuscarinic acetylcholine receptor M1P11229T2889311715630; 15738862; 15959450; 15627046
NauseaAlpha-1A adrenergic receptorP35348T9260911715630; 15738862; 15959450; 15627046
Nausea5-hydroxytryptamine receptor 2BP41595T3120411715630; 15738862; 15959450; 15627046
Nausea5-hydroxytryptamine receptor 2AP28223T3206011715630; 15738862; 15959450; 15627046
NauseaHistamine H1 receptorP35367T7791311715630; 15738862; 15959450; 15627046
Nausea5-hydroxytryptamine receptor 3AP46098T6459111715630; 15738862; 15959450; 15627046
PainNot AvailableQ5SUY9Not Available9168217; 9655623
ParkinsonismD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)5-hydroxytryptamine receptor 3AP46098T6459111715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)Muscarinic acetylcholine receptor M1P11229T2889311715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)Alpha-1A adrenergic receptorP35348T9260911715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)5-hydroxytryptamine receptor 2BP41595T3120411715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)5-hydroxytryptamine receptor 2AP28223T3206011715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)Histamine H1 receptorP35367T7791311715630; 15738862; 15959450; 15627046
Tardive dyskinesiaD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000814%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Aneurysm24.02.01.0010.000013%Not Available
Anger19.04.02.0010.000865%Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angular cheilitis23.03.03.054; 11.01.04.014; 07.05.07.013--Not Available
Ankylosing spondylitis15.01.09.001; 10.04.04.0040.000051%Not Available
Anorectal disorder07.03.01.001--Not Available
Anorgasmia19.08.01.0010.000356%
Anosmia22.04.03.006; 17.04.04.0010.000102%
Antisocial behaviour19.05.01.010--Not Available
Antisocial personality disorder19.05.03.002--Not Available
Anuria20.01.03.002--Not Available
Anxiety19.06.02.0020.003764%
Apathy19.04.04.0020.000254%Not Available
Aphasia17.02.03.001; 19.21.01.001--
Apnoea22.02.01.0010.000178%
Apraxia19.21.01.002; 17.02.03.002--Not Available
Areflexia17.02.01.0010.000153%Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.000331%
Arthropathy15.01.01.003--Not Available
Asocial behaviour19.05.01.011--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.0110.000020%Not Available
Aspiration22.02.07.007--
Asterixis17.01.06.001; 09.01.03.0040.000305%Not Available
Asthenia08.01.01.001--Not Available
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