Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Furosemide
Drug ID BADD_D00979
Description Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.[L7958] Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.[L7961] It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.[A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.[L7958]
Indications and Usage Furosemide is indicated for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome, in adults and pediatric patients.[L7958] Oral furosemide is indicated alone for the management of mild to moderate hypertension or severe hypertension in combination with other antihypertensive medications.[L9659] Intravenous furosemide is indicated as adjunctive therapy in acute pulmonary edema when a rapid onset of diuresis is desired.[L7958]
Marketing Status approved; vet_approved
ATC Code C03CA01
DrugBank ID DB00695
KEGG ID D00331
MeSH ID D005665
PubChem ID 3440
TTD Drug ID D0PQ3G
NDC Product Code 72603-474; 51552-0940; 51927-0077; 53002-4300; 55150-323; 61919-442; 63323-280; 63629-1120; 0378-0208; 0404-9864; 68083-432; 68083-433; 68083-434; 0409-6102; 70121-1076; 70860-302; 70934-737; 71335-0384; 71872-7236; 0615-8369; 0904-7177; 36000-063; 43063-849; 51655-310; 55154-9582; 66432-549; 67296-1469; 68071-1708; 68071-1809; 68071-4445; 69315-118; 70756-619; 72789-032; 63415-0025; 43063-806; 43353-747; 43547-402; 51079-073; 51662-1572; 60760-708; 63187-097; 63187-437; 63187-739; 69844-051; 70518-0050; 70518-0251; 70756-620; 70934-111; 0054-4297; 0054-4301; 0054-8297; 71872-7295; 60760-707; 63187-517; 63629-1216; 0378-0232; 64980-564; 67296-1547; 68071-3461; 68788-7354; 69315-116; 0054-3294; 71335-0842; 71335-1632; 0054-8299; 71610-636; 71872-7277; 72789-033; 72789-157; 42291-468; 42708-174; 43353-018; 43353-341; 43547-401; 50090-2560; 51407-113; 51407-114; 51662-1336; 52584-284; 63629-1119; 63629-1217; 64980-562; 0404-9863; 68094-756; 68094-867; 69315-117; 69844-052; 70121-1163; 70529-550; 71335-0397; 71872-7278; 49452-3222; 57451-0007; 36000-283; 43353-069; 50090-5429; 51655-481; 51662-1226; 51662-1574; 58118-0143; 60760-858; 70121-1164; 70518-0809; 70518-2766; 70529-061; 0054-3298; 72789-030; 48087-0053; 51927-1784; 71052-238; 30698-060; 30698-067; 36000-282; 60760-217; 61919-255; 63629-1215; 0378-0216; 64679-759; 68071-2313; 68071-3273; 70518-0836; 70529-062; 70529-549; 0054-8301; 71610-096; 71610-635; 0615-8370; 72603-251; 83284-002; 16729-500; 25021-311; 36000-284; 43547-403; 50090-5702; 50090-6219; 50090-6221; 51662-1227; 63187-506; 68071-4022; 71610-049; 17337-0087; 72166-003; 16729-502; 23155-473; 42708-123; 43063-702; 50090-3313; 50090-3338; 51079-072; 51079-527; 51407-115; 52584-283; 55150-322; 55150-324; 55154-2365; 63187-790; 63629-1214; 66432-550; 68071-3459; 68788-6784; 70518-3757; 70756-618; 0054-4299; 71288-203; 71335-0601; 71610-634; 71872-7127; 72572-190; 0904-7178; 57451-0006; 66326-401; 70193-0002; 42291-469; 53808-1109; 55154-4452; 55154-9581; 55700-452; 61919-242; 64980-563; 0404-9862; 0409-1639; 68788-6948; 68788-7265; 69844-053; 70518-3061; 71335-0852; 71610-284; 71872-7059; 0615-8368; 72603-133; 81565-201; 48087-0054; 51927-0078; 82348-105; 16729-501; 17224-178; 30698-066; 36000-064; 36000-065; 42291-470; 43063-716; 50090-3339; 51662-1575; 55154-2364; 55700-461
UNII 7LXU5N7ZO5
Synonyms Furosemide | Frusemide | Fursemide | Frusemid | Fusid | Lasix | Furosemide Monohydrochloride | Errolon | Furanthril | Furantral | Furosemide Monosodium Salt
Chemical Information
Molecular Formula C12H11ClN2O5S
CAS Registry Number 54-31-9
SMILES C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastric mucosal lesion07.11.03.0070.000014%Not Available
Malignant peritoneal neoplasm07.21.03.005; 16.13.04.0050.000014%Not Available
Lip exfoliation07.05.05.0200.000031%Not Available
Hypercreatinaemia15.05.03.021; 14.11.01.0240.000014%Not Available
Skin plaque23.03.03.0440.000014%Not Available
Narrow anterior chamber angle06.06.07.0040.000028%Not Available
Prerenal failure24.06.02.025; 20.01.03.0220.000104%Not Available
Hyponatraemic seizure17.12.03.025; 14.05.04.0080.000014%Not Available
Blister rupture23.03.01.027; 12.01.06.0120.000014%Not Available
Diabetic metabolic decompensation14.07.03.003; 05.07.03.0030.000021%Not Available
Haemorrhagic necrotic pancreatitis24.07.02.047; 07.18.01.0100.000014%Not Available
Unmasking of previously unidentified disease08.01.03.0800.000042%Not Available
End stage renal disease20.01.03.0190.000014%Not Available
Angiokeratoma24.03.03.045; 23.06.03.0070.000014%Not Available
Anisocoria17.02.11.009; 06.05.03.0130.000028%Not Available
Biliary obstruction09.02.02.0050.000035%Not Available
Blood loss anaemia24.07.01.088; 01.03.02.0180.000021%Not Available
Dilated cardiomyopathy02.04.01.0170.000021%Not Available
Drug use disorder19.07.06.0120.000028%Not Available
Fixed eruption23.03.05.008; 10.01.01.037; 08.01.06.0250.000028%Not Available
Hyperglycaemic hyperosmolar nonketotic syndrome17.02.04.022; 14.07.04.009; 05.07.04.0090.000028%Not Available
Immune thrombocytopenia10.02.01.083; 01.08.01.0130.000014%Not Available
Periorbital swelling23.04.01.025; 10.01.05.025; 06.08.03.0320.000021%Not Available
Physical deconditioning08.01.03.0960.000014%Not Available
Therapeutic product ineffective08.06.01.057--Not Available
Therapeutic response changed08.06.01.059--Not Available
Therapy non-responder08.06.01.0630.000193%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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