Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fospropofol disodium
Drug ID BADD_D00972
Description Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December 2008. Fospropofol is a Schedule IV controlled substance in the United States under the Controlled Substances Act.
Indications and Usage For monitored anaesthesia care sedation in patients undergoing diagnostic procedures like bronchoscopy and colonscopy or minor surgical procedures like arthroscopy and bunionectomy.
Marketing Status Discontinued
ATC Code N01AX10
DrugBank ID DB06716
KEGG ID D04257
MeSH ID C472965
PubChem ID 3038497
TTD Drug ID D02EZM
NDC Product Code 66064-1034
Synonyms fospropofol | Aquavan | Lusedra | fospropofol disodium | methanol, (2,6-bis(1-methylethyl)phenoxy)-, dihydrogen phosphate, disodium salt | GPI 15715 | GPI15715
Chemical Information
Molecular Formula C13H19Na2O5P
CAS Registry Number 258516-87-9
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)([O-])[O-].[Na+].[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Apnoea22.02.01.001--
Blood methanol increased13.17.02.005--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cough22.02.03.001--
Gastrointestinal disorder07.11.01.001--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Pruritus23.03.12.001--
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Skin disorder23.03.03.007--Not Available
Ventricular tachycardia02.03.04.010--
Vomiting07.01.07.003--
Angiopathy24.03.02.007--Not Available
Mediastinal disorder22.09.03.001--Not Available
Pulmonary function test decreased13.19.01.001--Not Available
Procedural pain12.02.05.007; 08.01.08.009--Not Available
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