| Pharmaceutical Information |
| Drug Name |
Fosfomycin tromethamine |
| Drug ID |
BADD_D00966 |
| Description |
Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by _Streptomyces fradiae_.[A229338,A230348] It may also be produced synthetically and is commercially available as the disodium salt for intravenous administration and as the calcium or trometamol salt for oral administration.[A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring.[A230348]
Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated urinary tract infections (UTIs) in females.[A230378] Despite being FDA approved only for urinary tract infections, fosfomycin actually has a broad spectrum of activity and is active against both gram-positive and gram-negative bacteria.[A230348] As such there is great interest in exploring the usefulness of fosfomycin for indications beyond the treatment of UTIs.[A230353,A230358] |
| Indications and Usage |
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis. |
| Marketing Status |
Prescription |
| ATC Code |
J01XX01 |
| DrugBank ID |
DB00828
|
| KEGG ID |
D00925
|
| MeSH ID |
D005578
|
| PubChem ID |
54331
|
| TTD Drug ID |
D01GYT
|
| NDC Product Code |
67877-749; 0456-4300; 69097-579; 69037-0066; 53069-1080; 82036-4274; 12836-0318 |
| Synonyms |
Fosfomycin | Phosphomycin | Phosphonomycin | Monuril | Fosfomycin Trometamol Salt | Fosfomycin Tromethamine | Tromethamine, Fosfomycin |
|
| Chemical Information |
| Molecular Formula |
C7H18NO7P |
| CAS Registry Number |
78964-85-9 |
| SMILES |
CC1C(O1)P(=O)(O)[O-].C(C(CO)(CO)[NH3+])O |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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