Drug Name |
Fosfomycin tromethamine |
Drug ID |
BADD_D00966 |
Description |
Fosfomycin was discovered in 1969 by scientists at the Spanish Penicillin and Antibiotics Company and is produced by _Streptomyces fradiae_.[A229338,A230348] It may also be produced synthetically and is commercially available as the disodium salt for intravenous administration and as the calcium or trometamol salt for oral administration.[A230348] In terms of chemical structure, fosfomycin is a phosphoenolpyruvate analog and contains a phosphonic group and an epoxide ring.[A230348]
Due to its ease of administration as a single 3-gram oral dose and desirable safety profile, fosfomycin has largely become a first-line therapeutic option for the treatment of uncomplicated urinary tract infections (UTIs) in females.[A230378] Despite being FDA approved only for urinary tract infections, fosfomycin actually has a broad spectrum of activity and is active against both gram-positive and gram-negative bacteria.[A230348] As such there is great interest in exploring the usefulness of fosfomycin for indications beyond the treatment of UTIs.[A230353,A230358] |
Indications and Usage |
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis. |
Marketing Status |
Prescription |
ATC Code |
J01XX01 |
DrugBank ID |
DB00828
|
KEGG ID |
D00925
|
MeSH ID |
D005578
|
PubChem ID |
54331
|
TTD Drug ID |
D01GYT
|
NDC Product Code |
67877-749; 0456-4300; 69097-579; 69037-0066; 53069-1080; 82036-4274; 12836-0318 |
Synonyms |
Fosfomycin | Phosphomycin | Phosphonomycin | Monuril | Fosfomycin Trometamol Salt | Fosfomycin Tromethamine | Tromethamine, Fosfomycin |