Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fosaprepitant
Drug ID BADD_D00962
Description Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Indications and Usage For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
Marketing Status Prescription; Discontinued
ATC Code A04AD12
DrugBank ID DB06717
KEGG ID D10895
MeSH ID C579707
PubChem ID 135413538
TTD Drug ID Not Available
NDC Product Code 71288-418; 67457-888; 71839-104; 16714-120; 43598-948; 70625-311; 68180-690; 72205-083; 69539-181; 63323-972; 72205-026; 60505-6105; 16714-929; 43598-859; 69097-830; 67457-889; 72603-106; 70710-1615; 68001-421; 16729-240; 72205-054; 68001-517; 0591-4385; 0781-3497; 69539-034
Synonyms fosaprepitant | Emend for injection | fosaprepitant dimeglumine | L 785,298 | L785,298 | L-785,298
Chemical Information
Molecular Formula C23H22F7N4O6P
CAS Registry Number 172673-20-0
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C( C=C4)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
Inner ear disorder04.04.02.002--Not Available
Blood disorder01.05.01.004--Not Available
Neutropenic colitis01.02.03.010; 07.08.01.014--Not Available
Infusion site thrombosis24.01.01.022; 12.07.05.007; 08.02.05.006--Not Available
Procedural nausea12.02.03.003; 07.01.07.005--Not Available
Gastrointestinal sounds abnormal07.01.01.002--Not Available
Oropharyngeal pain07.05.05.004; 22.02.05.022--
Upper-airway cough syndrome22.02.05.030--
Candida infection11.03.03.021--
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