Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fosaprepitant
Drug ID BADD_D00962
Description Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.
Indications and Usage For the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy.
Marketing Status Prescription; Discontinued
ATC Code A04AD12
DrugBank ID DB06717
KEGG ID D10895
MeSH ID C579707
PubChem ID 135413538
TTD Drug ID Not Available
NDC Product Code 71288-418; 67457-888; 71839-104; 16714-120; 43598-948; 70625-311; 68180-690; 72205-083; 69539-181; 63323-972; 72205-026; 60505-6105; 16714-929; 43598-859; 69097-830; 67457-889; 72603-106; 70710-1615; 68001-421; 16729-240; 72205-054; 68001-517; 0591-4385; 0781-3497; 69539-034
Synonyms fosaprepitant | Emend for injection | fosaprepitant dimeglumine | L 785,298 | L785,298 | L-785,298
Chemical Information
Molecular Formula C23H22F7N4O6P
CAS Registry Number 172673-20-0
SMILES CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C( C=C4)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000374%
Anaphylactic shock10.01.07.002; 24.06.02.0040.000748%Not Available
Anxiety19.06.02.002--
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.0050.001310%
Blood pressure increased13.14.03.005--Not Available
Blood urine13.13.02.011--Not Available
Bradycardia02.03.02.002--Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.009--Not Available
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000748%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.000935%Not Available
Chills15.05.03.016; 08.01.09.0010.000374%
Confusional state17.02.03.005; 19.13.01.0010.000374%
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Cough22.02.03.0010.000561%
Dermatitis23.03.04.002--Not Available
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.000561%
Drug hypersensitivity10.01.01.0010.000748%Not Available
Dry mouth07.06.01.002--
Duodenal ulcer perforation07.04.02.003--Not Available
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