Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluticasone propionate
Drug ID BADD_D00947
Description Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
Indications and Usage Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Marketing Status Prescription; OTC; Discontinued
ATC Code D07AC17; R01AD08; R03BA05
DrugBank ID DB00588
KEGG ID D01708
MeSH ID D000068298
PubChem ID 444036
TTD Drug ID D0LC6K
NDC Product Code 70518-1655; 65089-0033; 53943-006; 68071-4156; 15308-0200; 46122-338; 37808-205; 0363-0881; 11673-262; 60505-0847; 21130-122; 53002-1294; 63868-656; 50383-968; 50909-5175; 50090-0968; 0363-0652; 0173-0600; 70518-2930; 21130-680; 0363-5010; 63654-380; 55301-506; 41520-703; 21130-089; 50594-319; 41250-634; 68788-6926; 41250-933; 63629-8659; 71143-375; 50090-1978; 60505-0829; 50090-2267; 56062-107; 0173-0718; 11822-0901; 53873-079; 60505-6134; 0113-0285; 72559-002; 36800-222; 68196-208; 49035-362; 22552-0043; 80267-000; 0173-0719; 50090-0916; 69842-900; 69842-765; 38779-2760; 49348-182; 81522-005; 59310-200; 11673-220; 71205-443; 64918-1600; 41163-023; 0173-0602; 60505-0955; 30142-301; 55910-773; 68016-723; 64918-1118; 61919-930; 64525-8000; 63190-0520; 55700-714; 30142-258; 68196-210; 46122-684; 0713-0631; 50090-4410; 64918-1700; 59310-311; 60505-6167; 30142-767; 69256-061; 50090-2880; 50383-700; 0363-0024; 63629-8661; 53104-7531; 70518-1223; 68788-9678; 81522-002; 63868-400; 55700-680; 45802-222; 0135-0582; 53002-7692; 68391-133; 64525-6560; 53943-500; 50090-0934; 50090-2557; 60505-6205; 45802-221; 11822-7005; 45802-441; 63187-021; 49035-060; 55315-800; 68462-427; 64024-007; 62011-0269; 58175-0361; 37835-997; 53002-1310; 0713-0729; 72189-004; 11822-1177; 63940-501; 52482-001; 59310-525; 41520-553; 11822-5000; 63981-001; 60429-195; 50090-3513; 0173-0601; 72288-333; 63379-001; 49035-200; 68071-2582; 0168-0434; 50090-0910; 68788-7788; 11673-388; 69842-770; 68998-600; 46122-386; 63187-638; 63629-8662; 11822-7003; 36800-572; 16812-005; 59310-505; 0173-0720; 11673-103; 0536-1183; 37808-340; 55319-019; 49076-5501; 60505-6201; 10337-434; 63629-8660; 63187-959; 53002-7691; 52221-106; 55315-825; 68071-4868; 63187-957; 36800-128; 50090-1245; 0168-0332; 51672-4095; 11822-5001; 0113-7117; 72288-119; 59310-515; 53873-078; 0054-3270; 55910-607; 69842-757; 50090-3679; 49035-063; 68071-1638; 80159-201; 0113-0028; 68788-7658; 63629-8658; 69168-380; 55018-301; 63187-806; 50090-1187; 70000-0110; 0363-5012; 76420-106; 0135-0576; 60432-264; 41163-100; 59310-114; 0713-0632; 53002-7690; 69842-228; 79903-071; 68788-9925; 63629-8663; 51927-0013; 69306-016; 50090-3803; 50090-2484; 51552-1310; 76162-656
Synonyms Fluticasone | Flonase | Flovent HFA | HFA, Flovent | Cutivate | Fluticasone Propionate | Propionate, Fluticasone | Flixonase | Flixotide | Flovent
Chemical Information
Molecular Formula C25H31F3O5S
CAS Registry Number 80474-14-2
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000664%
Abdominal pain07.01.05.0020.000885%
Abdominal pain upper07.01.05.0030.000442%
Acne23.02.01.0010.000442%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.001659%
Adrenal suppression14.11.01.005; 05.01.02.0020.002102%Not Available
Adrenocortical insufficiency acute05.01.02.005; 14.11.01.0200.000442%Not Available
Ageusia17.02.07.001; 07.14.03.0030.000885%Not Available
Aggression19.05.01.0010.000442%Not Available
Agitation19.06.02.001; 17.02.05.0120.000442%
Alopecia23.02.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.000332%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anosmia17.04.04.001; 22.04.03.0060.001106%
Anxiety19.06.02.0020.001217%
Arrhythmia02.03.02.0010.000221%Not Available
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.0020.000221%Not Available
Asthma10.01.03.010; 22.03.01.0020.003871%Not Available
Back pain15.03.04.005--
Benign intracranial hypertension17.07.02.0010.000332%Not Available
Blindness17.17.01.003; 06.02.02.0010.000332%Not Available
Blister23.03.01.001; 12.01.06.002--Not Available
Blood cortisol decreased13.10.09.0040.000664%Not Available
Blood pressure decreased13.14.03.0020.000332%Not Available
Blood pressure increased13.14.03.0050.000332%Not Available
Body temperature increased13.15.01.001--Not Available
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